The synthesis and high-resolution NMR spectroscopy of ethyl N-(2-triphenylmethylthio)ethanoyl-O-(4'-[4''-(1''-bis(2'''-chloroethyl)amino)phenyl]butanoyl)-L-seryl-S-benzyl-L-cysteine: A chelate-chlorambucil complex for use as a ligand for Tc-99m radio-imaging

被引：12

作者：

Bell, RA

Hughes, DW

Lock, CJL

Valliant, JF

机构：

[1] MCMASTER UNIV,LAB INORGAN MED,DEPT BIOCHEM & PATHOL,HAMILTON,ON L8S 4M1,CANADA

[2] MCMASTER UNIV,NMR FACIL,HAMILTON,ON L8S 4M1,CANADA

来源：

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE | 1996年 / 74卷 / 08期

关键词：

ethyl N-triphenylmethylthioethanoyl-O-{4'-[4''-(1''-bis(2'''-chloroethyl)amino)phenyl]butanoyl}-L-seryl-S-benzyl-L-cysteine; NMR spectroscopy; synthesis; radio-imaging agent;

D O I：

10.1139/v96-167

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A potential agent for the imaging of tumours has been synthesized from the antineoplastic agent chlorambucil. Standard peptide coupling techniques were used to synthesize a tripeptide covalently coupled to chlorambucil in 10 steps. The final product was characterized by high-resolution NMR spectroscopy.

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页码：1503 / 1511

页数：9

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