Synaptic theory of working memory

被引：824

作者：

Mongillo, Gianluigi ^{[2
,3
]}

Barak, Omri ^{[1
]}

Tsodyks, Misha ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel

[2] Ecole Normale Super, Grp Neural Theory, Dept Etud Cognit, F-75231 Paris, France

[3] Coll France, F-75231 Paris, France

来源：

SCIENCE | 2008年 / 319卷 / 5869期

关键词：

D O I：

10.1126/science.1150769

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

It is usually assumed that enhanced spiking activity in the form of persistent reverberation for several seconds is the neural correlate of working memory. Here, we propose that working memory is sustained by calcium- mediated synaptic facilitation in the recurrent connections of neocortical networks. In this account, the presynaptic residual calcium is used as a buffer that is loaded, refreshed, and read out by spiking activity. Because of the long time constants of calcium kinetics, the refresh rate can be low, resulting in a mechanism that is metabolically efficient and robust. The duration and stability of working memory can be regulated by modulating the spontaneous activity in the network.

引用

页码：1543 / 1546

页数：4

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