The use of steroids in the treatment of severe sepsis and septic shock

被引：41

作者：

Batzofin, Baruch M. ^{[1
]}

Sprung, Charles L. ^{[1
]}

Weiss, Yoram G.

机构：

[1] Hadassah Hebrew Univ Med Ctr, Dept Anesthesiol & Crit Care Med, Gen Intens Care Unit, IL-9112 Jerusalem, Israel

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2011年 / 25卷 / 05期

关键词：

corticosteroids; hydrocortisone; sepsis; septic shock; steroids; HYDROCORTISONE; CORTICOSTEROIDS; MANAGEMENT; EFFICACY; THERAPY; MORTALITY; REVERSAL; SAFETY; ADULTS;

D O I：

10.1016/j.beem.2011.05.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sepsis and septic shock remain major causes of mortality and morbidity worldwide. Previously, high dose corticosteroids were used to dampen the inflammatory response but studies and meta-analyses showed this to be of no benefit and possibly detrimental. Subsequently, low dose corticosteroids were used in the treatment of sepsis and septic shock with the hypothesis that these conditions are associated with relative adrenal insufficiency. Although some studies showed promising results larger studies and meta-analyses have failed to reproduce these effects and the use of corticosteroids in the treatment of sepsis and septic shock remains controversial. We review the current literature and guidelines regarding low dose corticosteroid use in the management of sepsis and septic shock. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：735 / 743

页数：9

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