Some thoughts about the single crystal growth of small molecules

被引：105

作者：

Spingler, Bernhard ^{[1
]}

Schnidrig, Stephan ^{[1
]}

Todorova, Tonya ^{[1
]}

Wild, Ferdinand ^{[1
]}

机构：

[1] Univ Zurich, Inst Inorgan Chem, CH-8057 Zurich, Switzerland

来源：

CRYSTENGCOMM | 2012年 / 14卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

PROTEIN CRYSTALLIZATION; ORGANIC-COMPOUNDS; SOLVENTS; POLYMORPHISM; GEL; DIFFUSION; CHEMISTRY;

D O I：

10.1039/c1ce05624g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This highlight critically compares various techniques to grow single crystals when only a few milligrams are available of the compound of interest. The authors describe vapour diffusion, evaporation, cooling, and layering techniques, as well as crystallisation in gels. A table of successfully applied solvent/antisolvent combinations for initial screening is given. Additionally, a comprehensive table of 107 solvents with their boiling points, densities and dielectric constants helps to optimise the crystal growth.

引用

页码：751 / 757

页数：7

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