SNP identification and polymorphism analysis in exon 2 of the horse myostatin gene

被引：24

作者：

Baron, E. E. ^{[1
]}

Lopes, M. S. ^{[1
]}

Mendonca, D. ^{[1
]}

da Camara Machado, A. ^{[1
]}

机构：

[1] Univ Azores, Biotechnol Ctr Azores, Dept Agr, P-9700042 Sao Pedro, Angra Do Herois, Portugal

来源：

ANIMAL GENETICS | 2012年 / 43卷 / 02期

关键词：

Equus caballus; Myostatin; polymorphism; MUSCLE MASS; MUTATIONS; TRAITS; GROWTH; CATTLE;

D O I：

10.1111/j.1365-2052.2011.02229.x

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

090502 [动物营养与饲料科学];

摘要：

The myostatin gene (MSTN) belongs to the TGF-beta superfamily of secreted growth and differentiation factors and is responsible for embryonic and adult skeletal muscle development. In this study, exon 2 of the MSTN gene, which encodes part of the TGF-beta pro-peptide, was sequenced in 332 horses of 20 different breeds and compared with the horse MSTN gene sequence deposited in GenBank. The sequences obtained revealed the presence of 11 haplotypes represented by 10 variable nucleotide mutations, eight of them corresponding to amino acid sequence changes. This gene shows a high variability when compared with other genes. This might be an indication that some breeds have the same ancestry but different pressures of selection.

引用

页码：229 / 232

页数：4

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