Reactivation of hepatitis B virus replication accompanied by acute hepatitis in patients receiving highly active antiretroviral therapy

被引：101

作者：

Manegold, C

Hannoun, C

Wywiol, A

Dietrich, M

Polywka, S

Chiwakata, CB

Günther, S

机构：

[1] Bernhard Nocht Inst Trop Med, Klin Abt, D-20359 Hamburg, Germany

[2] Bernhard Nocht Inst Trop Med, Abt Virol, D-20359 Hamburg, Germany

[3] Univ Hamburg, Krankenhaus Eppendorf, Inst Med Mikrobiol & Immunol, D-2000 Hamburg, Germany

来源：

CLINICAL INFECTIOUS DISEASES | 2001年 / 32卷 / 01期

关键词：

D O I：

10.1086/317535

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe 2 patients who were initially positive for antibodies to hepatitis B surface antigen and who experienced a strong and sudden increase of hepatitis B virus (HBV) replication during highly active antiretroviral therapy (HAART). We found that reactivation of HBV replication during HAART can occur independently of lamivudine resistance or withdrawal of lamivudine, and in spite of increasing CD4(+) cell counts.

引用

收藏

页码：144 / 148

页数：5

相关论文

共 25 条

[1] Identification and characterization of mutations in hepatitis B virus resistant to lamivudine [J].

Allen, MI ;

Deslauriers, M ;

Andrews, CW ;

Tipples, GA ;

Walters, KA ;

Tyrrell, DLJ ;

Brown, N ;

Condreay, LD .

HEPATOLOGY, 1998, 27 (06) :1670-1677

[2] Reactivation of hepatitis B in a long-term anti-HBs-positive patient with AIDS following lamivudine withdrawal [J].

Altfeld, M ;

Rockstroh, JK ;

Addo, M ;

Kupfer, B ;

Pult, I ;

Will, H ;

Spengler, U .

JOURNAL OF HEPATOLOGY, 1998, 29 (02) :306-309

[3] An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses [J].

André, P ;

Groettrup, M ;

Klenerman, P ;

de Giuli, R ;

Booth, BL ;

Cerundolo, V ;

Bonneville, M ;

Jotereau, F ;

Zinkernagel, RM ;

Lotteau, V .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) :13120-13124

[4] Hepatitis-B-virus resistance to lamivudine given for recurrent infection after orthotopic liver transplantation [J].

Bartholomew, MM ;

Jansen, RW ;

Jeffers, LJ ;

Reddy, KR ;

Johnson, LC ;

Bunzendahl, H ;

Condreay, LD ;

Tzakis, AG ;

Schiff, ER ;

Brown, NA .

LANCET, 1997, 349 (9044) :20-22

[5] Chronic active hepatitis B exacerbations in human immunodeficiency virus-infected patients following development of resistance to or withdrawal of lamivudine [J].

Bessesen, M ;

Ives, D ;

Condreay, L ;

Lawrence, S ;

Sherman, KE .

CLINICAL INFECTIOUS DISEASES, 1999, 28 (05) :1032-1035

[6] Severe hepatitis in three AIDS patients treated with indinavir [J].

Brau, N ;

Leaf, HL ;

Wieczorek, RL ;

Margolis, DM .

LANCET, 1997, 349 (9056) :924-925

[7] VACCINE-INDUCED ESCAPE MUTANT OF HEPATITIS-B VIRUS [J].

CARMAN, WF ;

ZANETTI, AR ;

KARAYIANNIS, P ;

WATERS, J ;

MANZILLO, G ;

TANZI, E ;

ZUCKERMAN, AJ ;

THOMAS, HC .

LANCET, 1990, 336 (8711) :325-329

[8] Restoration of immunity to chronic hepatitis B infection in HIV-infected patient on protease inhibitor [J].

Carr, A ;

Cooper, DA .

LANCET, 1997, 349 (9057) :995-996

[9] Emergence and takeover of YMDD motif mutant hepatitis B virus during long-term lamivudine therapy and re-takeover by wild type after cessation of therapy [J].

Chayama, K ;

Suzuki, Y ;

Kobayashi, M ;

Kobayashi, M ;

Tsubota, A ;

Hashimoto, M ;

Miyano, Y ;

Koike, H ;

Kobayashi, M ;

Koida, I ;

Arase, Y ;

Saitoh, S ;

Murashima, N ;

Ikeda, K ;

Kumada, H .

HEPATOLOGY, 1998, 27 (06) :1711-1716

[10] Discontinuous epitopes of hepatitis B surface antigen derived from a filamentous phage peptide library [J].

Chen, YCJ ;

Delbrook, K ;

Dealwis, C ;

Mimms, L ;

Mushahwar, IK ;

Mandecki, W .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (05) :1997-2001