Bioactive oleanolic acid saponins and other constituents from the roots of Viguiera decurrens

被引：77

作者：

Marquina, S

Maldonado, N

Garduño-Ramírez, ML

Aranda, E

Villarreal, ML

Navarro, V

Bye, R

Delgado, G

Alvarez, L

机构：

[1] Univ Autonoma Estado Morelos, Ctr Invest Quim, Cuernavaca 62210, Morelos, Mexico

[2] Univ Autonoma Estado Morelos, Ctr Invest Biotecnol, Cuernavaca 62210, Morelos, Mexico

[3] Ctr Invest Biomed Sur, Inst Mexicano Seguro Social, Xochitepec, Morelos, Mexico

[4] Natl Autonomous Univ Mexico, Inst Biol, Mexico City 04510, DF, Mexico

[5] Natl Autonomous Univ Mexico, Inst Quim, Mexico City 04510, DF, Mexico

来源：

PHYTOCHEMISTRY | 2001年 / 56卷 / 01期

关键词：

Viguiera decurrens; Asteraceae; root; oleanolic acid; bisdesmoside; saponin; chikusetsusaponin methyl ester; cytotoxic and insecticidal activity;

D O I：

10.1016/S0031-9422(00)00283-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The bisdesmoside oleanolic acid saponin, 3-O-(methyl-beta -D-glucuronopyranosiduronoate)-28-O-beta -D-glucopyranosyl-oleanolate, along with nine known compounds (two diterpenic acids, one chromene, three triterpenes. one steroidal glycoside, and two monodesmoside oleanolic acid saponins). were obtained from Viguiera decurrens roots. The chemical structure of the bisdesmoside oleanolic saponin was determined by chemical and NMR spectral evidence. A mixture of monodesmoside saponins displayed cytotoxic activity against P388 and COLON cell lines (ED50 = 2.3 and 3.6 mug/ml, respectively). Two of the known compounds showed insecticidal activity against the Mexican bran beetle larvae (Epilachna varivestis). (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：93 / 97

页数：5

共 24 条

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