Membrane-anchored peptide inhibits human immunodeficiency virus entry

被引：101

作者：

Hildinger, M

Dittmar, MT

Schult-Dietrich, P

Fehse, B

Schnierle, BS

Thaler, S

Stiegler, G

Welker, R

von Laer, D ^{[1
]}

机构：

[1] Georg Speyer Haus, Paul Ehrlich Str 42-44, D-60596 Frankfurt, Germany

[2] Univ Hamburg, Heinrich Pette Inst Expt Virol & Immunol, D-20251 Hamburg, Germany

[3] Univ Hamburg, Krankenhaus Eppendorf, Zentrum Knochenmarktransplantat, D-20251 Hamburg, Germany

[4] Inst Appl Microbiol, A-1190 Vienna, Austria

来源：

JOURNAL OF VIROLOGY | 2001年 / 75卷 / 06期

关键词：

D O I：

10.1128/JVI.75.6.3038-3042.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Peptides derived from the heptad repeats of human immunodeficiency virus (HIV) gp41 envelope glycoprotein, such as T20, can efficiently inhibit HIV type 1 (HIV-1) entry. In this study, replication of HTV-1 was inhibited more than 100-fold in a T-helper cell line transduced with a retrovirus vector expressing membrane-anchored T20 on the cell surface. Inhibition was independent of coreceptor usage.

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收藏

页码：3038 / 3042

页数：5

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