The PI3K inhibitor arsenal: choose your weapon!

被引:76
作者
Crabbe, Tom [1 ]
Welham, Melanie J.
Ward, Stephen G.
机构
[1] Univ Bath, Inflammatory Cell Biol Lab, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England
[2] Univ Bath, Mol Signalling Lab, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England
[3] UCB Celltech, Slough SL1 4EN, Berks, England
基金
英国生物技术与生命科学研究理事会;
关键词
D O I
10.1016/j.tibs.2007.09.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Owing to its widespread activation in inflammation and cancer, a growing appreciation of the therapeutic potential of inhibitors of the phosphoinositide 3-kinase (PI3K) pathway has stimulated intense interest in compounds with suitable pharmacological profiles. These are primarily directed toward PI3K itself. However, as class I PI3Ks are also essential for a range of normal physiological processes, broad spectrum PI3K inhibition could be poorly tolerated. In recent years, patents describing a new generation of PI3K inhibitors have started to appear, with a particular focus on the development of compounds with enhanced isoform selectivity for use as anti-cancer and anti-inflammatory therapies. However, challenges remain for the efforts to pharmacologically target this enzyme family in a successful manner.
引用
收藏
页码:450 / 456
页数:7
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