Controlling mutation: intervening in evolution as a therapeutic strategy

被引:49
作者
Cirz, Ryan T. [1 ]
Romesberg, Floyd E. [1 ]
机构
[1] Scripps Res Inst, La Jolla, CA 92037 USA
关键词
induced mutation; antibiotic resistance; SOS response;
D O I
10.1080/10409230701597741
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mutation is the driving force behind many processes linked to human disease, including cancer, aging, and the evolution of drug resistance. Mutations have traditionally been considered the inevitable consequence of replicating large genomes with polymerases of finite fidelity. Observations over the past several decades, however, have led to a new perspective on the process of mutagenesis. It has become clear that, under some circumstances, mutagenesis is a regulated process that requires the induction of pro-mutagenic enzymes and that, at least in bacteria, this induction may facilitate evolution. Herein, we review what is known about induced mutagenesis in bacteria as well as evidence that it contributes to the evolution of antibiotic resistance. Finally, we discuss the possibility that components of induced mutation pathways might be targeted for inhibition as a novel therapeutic strategy to prevent the evolution of antibiotic resistance.
引用
收藏
页码:341 / 354
页数:14
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