Gene Ontology Consortium: going forward

被引：1192

作者：

Blake, J. A. ^{[1
]}

Christie, K. R. ^{[1
]}

Dolan, M. E. ^{[1
]}

Drabkin, H. J. ^{[1
]}

Hill, D. P. ^{[1
]}

Ni, L. ^{[1
]}

Sitnikov, D. ^{[1
]}

Burgess, S. ^{[2
]}

Buza, T. ^{[2
]}

Gresham, C. ^{[2
]}

McCarthy, F. ^{[2
]}

Pillai, L. ^{[2
]}

Wang, H. ^{[2
]}

Carbon, S. ^{[3
]}

Dietze, H. ^{[3
]}

Lewis, S. E. ^{[3
]}

Mungall, C. J. ^{[3
]}

Munoz-Torres, M. C. ^{[3
]}

Feuermann, M. ^{[4
]}

Gaudet, P. ^{[4
]}

Basu, S. ^{[5
]}

Chisholm, R. L. ^{[5
]}

Dodson, R. J. ^{[5
]}

Fey, P. ^{[5
]}

Mi, H. ^{[6
]}

Thomas, P. D. ^{[6
]}

Muruganujan, A. ^{[6
]}

Poudel, S. ^{[6
]}

Hu, J. C. ^{[7
,8
]}

Aleksander, S. A. ^{[7
,8
]}

McIntosh, B. K. ^{[7
,8
]}

Renfro, D. P. ^{[7
,8
]}

Siegele, D. A. ^{[7
,8
]}

Attrill, H. ^{[9
,10
]}

Brown, N. H. ^{[9
,10
]}

Tweedie, S. ^{[9
,10
]}

Lomax, J. ^{[11
]}

Osumi-Sutherland, D. ^{[11
]}

Parkinson, H. ^{[11
]}

Roncaglia, P. ^{[11
]}

Lovering, R. C. ^{[12
]}

Talmud, P. J. ^{[12
]}

Humphries, S. E. ^{[12
]}

Denny, P. ^{[12
]}

Campbell, N. H. ^{[12
]}

Foulger, R. E. ^{[12
]}

Chibucos, M. C. ^{[13
]}

Giglio, M. Gwinn ^{[13
]}

Chang, H. Y. ^{[14
]}

Finn, R. ^{[14
]}

机构：

[1] Jackson Lab, MGI, Bar Harbor, ME 04609 USA

[2] Mississippi State Univ, AgBase, Starkville, MS USA

[3] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Berkeley Bioinformat Open Source Projects, Genom Div, Berkeley, CA 94720 USA

[4] SIB, CALIPHO Grp, Geneva, Switzerland

[5] Northwestern Univ, DictyBase, Chicago, IL 60611 USA

[6] Univ So Calif, Dept Prevent Med, Div Bioinformat, Los Angeles, CA 90089 USA

[7] Texas A&M Univ, Dept Biol, EcoliWiki, College Stn, TX 77843 USA

[8] Texas A&M Univ, Dept Biochem & Biophys, EcoliWiki, College Stn, TX 77843 USA

[9] Univ Cambridge, Gurdon Inst, FlyBase, Cambridge, England

[10] Univ Cambridge, Dept Genet, Cambridge, England

[11] GO EMBL EBI, Hinxton, England

[12] UCL, Inst Cardiovasc Sci, London, England

[13] Univ Maryland, Sch Med, Inst Genome Sci, Baltimore, MD 21201 USA

[14] EMBL EBI, InterPro, Hinxton, England

[15] Collect & Refinement Physiol Data Mycobacterium, Berlin, Germany

[16] Univ Cambridge, PomBase, Cambridge, England

[17] UCL, PomBase, London, England

[18] EMBL EBI, PomBase, Hinxton, England

[19] Med Coll Wisconsin, RGD, Milwaukee, WI 53226 USA

[20] NYU, Sch Med, Reactome, Dept Biochem & Mol Pharmacol, New York, NY USA

[21] Stanford Univ, Dept Genet, SGD, Stanford, CA 94305 USA

[22] Phoenix Bioinformat, TAIR, Redwood City, CA USA

[23] UniProt EMBL EBI, Hinxton, England

[24] SIB, Geneva, Switzerland

[25] Prot Informat Resource, Washington, DC USA

[26] CALTECH, WormBase, Pasadena, CA 91125 USA

[27] Univ Oregon, ZFIN, Eugene, OR 97403 USA

来源：

NUCLEIC ACIDS RESEARCH | 2015年 / 43卷 / D1期

基金：

美国国家卫生研究院; 英国生物技术与生命科学研究理事会;

关键词：

ANNOTATIONS; ANATOMY; DATABASE; TOOL;

D O I：

10.1093/nar/gku1179

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Gene Ontology (GO; ext-link-type="uri" xlink:href="http://www.geneontology.org" xlink:type="simple">http://www.geneontology.org) is a community-based bioinformatics resource that supplies information about gene product function using ontologies to represent biological knowledge. Here we describe improvements and expansions to several branches of the ontology, as well as updates that have allowed us to more efficiently disseminate the GO and capture feedback from the research community. The Gene Ontology Consortium (GOC) has expanded areas of the ontology such as cilia-related terms, cell-cycle terms and multicellular organism processes. We have also implemented new tools for generating ontology terms based on a set of logical rules making use of templates, and we have made efforts to increase our use of logical definitions. The GOC has a new and improved web site summarizing new developments and documentation, serving as a portal to GO data. Users can perform GO enrichment analysis, and search the GO for terms, annotations to gene products, and associated metadata across multiple species using the all-new AmiGO 2 browser. We encourage and welcome the input of the research community in all biological areas in our continued effort to improve the Gene Ontology.

引用

页码：D1049 / D1056

页数：8

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