Genome-based and transcriptome-based molecular classification of breast cancer

被引：14

作者：

Bieche, Ivan ^{[1
]}

Lidereau, Rosette ^{[1
]}

机构：

[1] Hop Rene Huguenin, Inst Curie, Lab Oncogenet, F-92210 St Cloud, France

来源：

CURRENT OPINION IN ONCOLOGY | 2011年 / 23卷 / 01期

关键词：

breast cancer; classification; epigenetic alterations; genetic alterations; LONG NONCODING RNAS; COLORECTAL CANCERS; MESENCHYMAL TRANSITION; PIK3CA MUTATIONS; GENE-EXPRESSION; CELL-LINE; METASTASIS; RESISTANCE; CARCINOMA; SEQUENCES;

D O I：

10.1097/CCO.0b013e3283412ee0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Purpose of review The highly heterogeneous clinical, histological, biological and genetic nature of breast malignancies is due in part to their extreme molecular complexity. Recent findings Many genetic and epigenetic alterations have been described, affecting a relatively small number of signaling pathways (PI3K, NK-kappa B, FGF, etc.) and thus several molecular subtypes of breast cancer have been identified. Summary The next decade will see even more prolific developments, notably with the advent of next-generation sequencing (NGS) technologies capable of providing individual patients' constitutional and somatic genome sequences both rapidly and cheaply. Knowledge of the full catalogue of somatic genetic alterations will pave the way for fully individualized management of breast cancer patients.

引用

页码：93 / 99

页数：7

共 62 条

[1]

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol [J].

Anand, S ;

Penrhyn-Lowe, S ;

Venkitaraman, AR .

CANCER CELL, 2003, 3 (01) :51-62

[2]

Frequent somatic mutations of GATA3 in non-BRCA1/BRCA2 familial breast tumors, but not in BRCA1-, BRCA2- or sporadic breast tumors [J].

Arnold, Jeremy M. ;

Choong, David Y. H. ;

Thompson, Ella R. ;

Waddell, Nic ;

Lindeman, Geoffrey J. ;

Visvader, Jane E. ;

Campbell, Ian G. ;

Chenevix-Trench, Georgia .

BREAST CANCER RESEARCH AND TREATMENT, 2010, 119 (02) :491-496

[3]

A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer [J].

Berns, Katrien ;

Horlings, Hugo M. ;

Hennessy, Bryan T. ;

Madiredjo, Mandy ;

Hijmans, E. Marielle ;

Beelen, Karin ;

Linn, Sabine C. ;

Gonzalez-Angulo, Ana Maria ;

Stemke-Hale, Katherine ;

Hauptmann, Michael ;

Beijersbergen, Roderick L. ;

Mills, Gordon B. ;

de Vijver, Marc J. van ;

Bernards, Rene .

CANCER CELL, 2007, 12 (04) :395-402

[4]

The landscape of somatic copy-number alteration across human cancers [J].

Beroukhim, Rameen ;

Mermel, Craig H. ;

Porter, Dale ;

Wei, Guo ;

Raychaudhuri, Soumya ;

Donovan, Jerry ;

Barretina, Jordi ;

Boehm, Jesse S. ;

Dobson, Jennifer ;

Urashima, Mitsuyoshi ;

Mc Henry, Kevin T. ;

Pinchback, Reid M. ;

Ligon, Azra H. ;

Cho, Yoon-Jae ;

Haery, Leila ;

Greulich, Heidi ;

Reich, Michael ;

Winckler, Wendy ;

Lawrence, Michael S. ;

Weir, Barbara A. ;

Tanaka, Kumiko E. ;

Chiang, Derek Y. ;

Bass, Adam J. ;

Loo, Alice ;

Hoffman, Carter ;

Prensner, John ;

Liefeld, Ted ;

Gao, Qing ;

Yecies, Derek ;

Signoretti, Sabina ;

Maher, Elizabeth ;

Kaye, Frederic J. ;

Sasaki, Hidefumi ;

Tepper, Joel E. ;

Fletcher, Jonathan A. ;

Tabernero, Josep ;

Baselga, Jose ;

Tsao, Ming-Sound ;

Demichelis, Francesca ;

Rubin, Mark A. ;

Janne, Pasi A. ;

Daly, Mark J. ;

Nucera, Carmelo ;

Levine, Ross L. ;

Ebert, Benjamin L. ;

Gabriel, Stacey ;

Rustgi, Anil K. ;

Antonescu, Cristina R. ;

Ladanyi, Marc ;

Letai, Anthony .

NATURE, 2010, 463 (7283) :899-905

[5]

Berx G, 1996, ONCOGENE, V13, P1919

[6]

MicroRNA signatures in human cancers [J].

Calin, George A. ;

Croce, Carlo M. .

NATURE REVIEWS CANCER, 2006, 6 (11) :857-866

[7]

MMTV-induced mammary tumorigenesis: gene discovery, progression to malignancy and cellular pathways [J].

Callahan, R ;

Smith, GH .

ONCOGENE, 2000, 19 (08) :992-1001

[8]

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer [J].

Carpten, John D. ;

Faber, Andrew L. ;

Horn, Candice ;

Donoho, Gregory P. ;

Briggs, Stephen L. ;

Robbins, Christiane M. ;

Hostetter, Galen ;

Boguslawski, Sophie ;

Moses, Tracy Y. ;

Savage, Stephanie ;

Uhlik, Mark ;

Lin, Aimin ;

Du, Jian ;

Qian, Yue-Wei ;

Zeckner, Douglas J. ;

Tucker-Kellogg, Greg ;

Touchman, Jeffrey ;

Patel, Ketan ;

Mousses, Spyro ;

Bittner, Michael ;

Schevitz, Richard ;

Lai, Mei-Huei T. ;

Blanchard, Kerry L. ;

Thomas, James E. .

NATURE, 2007, 448 (7152) :439-U1

[9]

Breast Cancer Cell Lines Contain Functional Cancer Stem Cells with Metastatic Capacity and a Distinct Molecular Signature [J].

Charafe-Jauffret, Emmanuelle ;

Ginestier, Christophe ;

Iovino, Flora ;

Wicinski, Julien ;

Cervera, Nathalie ;

Finetti, Pascal ;

Hur, Min-Hee ;

Diebel, Mark E. ;

Monville, Florence ;

Dutcher, Julie ;

Brown, Marty ;

Viens, Patrice ;

Xerri, Luc ;

Bertucci, Francois ;

Stassi, Giorgio ;

Dontu, Gabriela ;

Birnbaum, Daniel ;

Wicha, Max S. .

CANCER RESEARCH, 2009, 69 (04) :1302-1313

[10]

Genomic and transcriptional aberrations linked to breast cancer pathophysiologies [J].

Chin, Koei ;

DeVries, Sandy ;

Fridlyand, Jane ;

Spellman, Paul T. ;

Roydasgupta, Ritu ;

Kuo, Wen-Lin ;

Lapuk, Anna ;

Neve, Richard M. ;

Qian, Zuwei ;

Ryder, Tom ;

Chen, Fanqing ;

Feiler, Heidi ;

Tokuyasu, Taku ;

Kingsley, Chris ;

Dairkee, Shanaz ;

Meng, Zhenhang ;

Chew, Karen ;

Pinkel, Daniel ;

Jain, Ajay ;

Ljung, Britt Marie ;

Esserman, Laura ;

Albertson, Donna G. ;

Waldman, Frederic M. ;

Gray, Joe W. .

CANCER CELL, 2006, 10 (06) :529-541

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