An EST and STS-based YAC contig map of human chromosome 9q22.3

被引：13

作者：

Lench, NJ ^{[1
]}

Telford, EA ^{[1
]}

Andersen, SE ^{[1
]}

Moynihan, TP ^{[1
]}

Robinson, PA ^{[1
]}

Markham, AF ^{[1
]}

机构：

[1] LEEDS DENT INST, LEEDS LS2 9LU, W YORKSHIRE, ENGLAND

来源：

GENOMICS | 1996年 / 38卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1006/geno.1996.0616

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have isolated 48 yeast artificial chromosome (YAC) clones from a 4 cM/27 cR region of human chromosome 9q22.3 encompassed by the markers cenD9S196-D9S173-tel. Within this region, we have assembled a 4.3-Mb YAC contig across the interval cen-FACC-D9S173-tel containing 42 clones. As a first step toward completing the detailed transcription map of the region, we have mapped 9 gene sequences and 10 expressed sequence tags. Fifteen polymorphic microsatellite repeat markers and 17 novel sequence-tagged sites from the region are also described. The mapping of polymorphic simple tandem repeat markers has permitted the integration of existing genetic and physical maps of the region. Together these maps provide a valuable resource for fine structure mapping and DNA sequencing across the region as well as for the identification of disease gene loci and the isolation of novel coding sequences. (C) 1996 Academic Press, Inc.

引用

页码：199 / 205

页数：7

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