Breaking down cell cycle checkpoints and DNA repair during antigen receptor gene assembly

被引：21

作者：

Callen, E. ^{[1
]}

Nussenzweig, M. C.

Nussenzweig, A.

机构：

[1] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA

[2] Rockefeller Univ, Lab Mol Immunol, New York, NY 10021 USA

[3] Howard Hughes Med Inst, New York, NY USA

来源：

ONCOGENE | 2007年 / 26卷 / 56期

基金：

美国国家卫生研究院;

关键词：

DNA repair; cell cycle checkpoints; class-switching; V(D)J recombination; ATM; lymphoma;

D O I：

10.1038/sj.onc.1210873

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Double-strand breaks (DSBs) are intermediates in several physiological processes including V(D)J and class switch recombination. They are also potent substrates for chromosomal translocations that arise as by-products of antigen receptor gene assembly in lymphocytes. ATM is one among several key proteins involved in the detection, signaling and repair of DNA breaks. Despite redundancies in DSB signaling pathways, it has recently been demonstrated that ATM deficient lymphocytes can survive and proliferate several generations in vitro and in vivo despite harboring terminally deleted chromosomes produced by V(D)J recombination. In this review, we discuss how two complementary genome maintenance functions mediated by ATM prevent lymphocytes from adapting to persistent DNA damage.

引用

页码：7759 / 7764

页数：6

共 58 条

[1] AWA A A, 1978, Journal of Radiation Research, V19, P126, DOI 10.1269/jrr.19.126
[2] Histone H2AX: A dosage-dependent suppressor of oncogenic translocations and tumors
Bassing, CH
Suh, H
Ferguson, DO
Chua, KF
Manis, J
Eckersdorff, M
Gleason, M
Bronson, R
Lee, C
Alt, FW
[J]. CELL, 2003, 114 (03) : 359 - 370
[3] Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX
Bassing, CH
Chua, KF
Sekiguchi, J
Suh, H
Whitlow, SR
Fleming, JC
Monroe, BC
Ciccone, DN
Yan, C
Vlasakova, K
Livingston, DM
Ferguson, DO
Scully, R
Alt, FW
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (12) : 8173 - 8178
[4] Bertoni F, 1999, GENE CHROMOSOME CANC, V26, P176, DOI 10.1002/(SICI)1098-2264(199910)26:2<176::AID-GCC11>3.0.CO
[5] 2-3
[6] ATM stabilizes DNA double-strand-break complexes during V(D)J recombination
Bredemeyer, Andrea L.
Sharma, Girdhar G.
Huang, Ching-Yu
Helmink, Beth A.
Walker, Laura M.
Khor, Katrina C.
Nuskey, Beth
Sullivan, Kathleen E.
Pandita, Tej K.
Bassing, Craig H.
Sleckman, Barry P.
[J]. NATURE, 2006, 442 (7101) : 466 - 470
[7] ATM prevents the persistence and propagation of chromosome breaks in lymphocytes
Callen, Elsa
Jankovic, Mila
Difilippantonio, Simone
Daniel, Jeremy A.
Chen, Hua-Tang
Celeste, Arkady
Pellegrini, Manuela
McBride, Kevin
Wangsa, Danny
Bredemeyer, Andrea L.
Sleckman, Barry P.
Ried, Thomas
Nussenzweig, Michel
Nussenzweig, Andre
[J]. CELL, 2007, 130 (01) : 63 - 75
[8] Genomic instability in mice lacking histone H2AX
Celeste, A
Petersen, S
Romanienko, PJ
Fernandez-Capetillo, O
Chen, HT
Sedelnikova, OA
Reina-San-Martin, B
Coppola, V
Meffre, E
Difilippantonio, MJ
Redon, C
Pilch, DR
Olaru, A
Eckhaus, M
Camerini-Otero, RD
Tessarollo, L
Livak, F
Manova, K
Bonner, WM
Nussenzweig, MC
Nussenzweig, A
[J]. SCIENCE, 2002, 296 (5569) : 922 - 927
[9] H2AX haploinsufficiency modifies genomic stability and tumor susceptibility
Celeste, A
Difilippantonio, S
Difilippantonio, MJ
Fernandez-Capetillo, O
Pilch, DR
Sedelnikova, OA
Eckhaus, M
Ried, T
Bonner, WM
Nussenzweig, A
[J]. CELL, 2003, 114 (03) : 371 - 383
[10] Response to RAG-mediated V(D)J cleavage by NBS1 and γ-H2AX
Chen, HT
Bhandoola, A
Difilippantonio, MJ
Zhu, J
Brown, MJ
Tai, XG
Rogakou, EP
Brotz, TM
Bonner, WM
Ried, T
Nussenzweig, A
[J]. SCIENCE, 2000, 290 (5498) : 1962 - 1964

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