Characterization of graft-versus-leukemia responses in patients treated for advanced chronic lymphocytic leukemia with donor lymphocyte infusions after in vitro T-cell depleted allogeneic stem cell transplantation following reduced-intensity conditioning

被引:14
作者
Hoogendoorn, M. [1 ]
Jedema, I. [1 ]
Barge, R. M. Y. [1 ]
van Luxemburg, S. A. P. [1 ]
Beaumont, Heijs F. [1 ]
Marijt, E. W. A. [1 ]
Willemze, R. [1 ]
Falkenburg, J. H. F. [1 ]
机构
[1] Leiden Univ, Dept Hematol, Lab Expt Hematol, Med Ctr, Leiden, Netherlands
关键词
D O I
10.1038/sj.leu.2404838
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:2569 / 2574
页数:7
相关论文
共 8 条
[1]   Minimal GVHD following in-vitro T cell-depleted allogeneic stem cell transplantation with reduced-intensity conditioning allowing subsequent infusions of donor lymphocytes in patients with hematological malignancies and solid tumors [J].
Barge, RMY ;
Osanto, S ;
Marijt, WAFE ;
Starrenburg, CWJI ;
Fibbe, WE ;
Nortier, JWRH ;
Falkenburg, JHF ;
Willemze, R .
EXPERIMENTAL HEMATOLOGY, 2003, 31 (10) :865-872
[2]   Results of alemtuzumab-based reduced-intensity allogeneic transplantation for chronic lymphocytic leukemia: a British Society of Blood and Marrow Transplantation Study [J].
Delgado, J ;
Thomson, K ;
Russell, N ;
Ewing, J ;
Stewart, W ;
Cook, G ;
Devereux, S ;
Lovell, R ;
Chopra, R ;
Marks, DI ;
Mackinnon, S ;
Milligan, DW .
BLOOD, 2006, 107 (04) :1724-1730
[3]   Generation of B-cell chronic lymphocytic leukemia (B-CLL)-reactive T-cell lines and clones from HLA class I-matched donors using modified B-CLL cells as stimulators: implications for adoptive immunotherapy [J].
Hoogendoorn, M ;
Wolbers, JO ;
Smit, WM ;
Schaafsma, MR ;
Barge, RMY ;
Willemze, R ;
Falkenburg, JHF .
LEUKEMIA, 2004, 18 (07) :1278-1287
[4]   Early detection and rapid isolation of leukemia-reactive donor T cells for adoptive transfer using the IFN-γ secretion assay [J].
Jedema, Inge ;
Meij, Pauline ;
Steeneveld, Esther ;
Hoogendoorn, Mels ;
Nijmeijer, Bart A. ;
van de Meent, Marian ;
van Luxemburg-Heijs, Simone A. P. ;
Willemze, Roel ;
Falkenburg, J. H. Frederik .
CLINICAL CANCER RESEARCH, 2007, 13 (02) :636-643
[5]   Allogeneic stem-cell transplantation may overcome the adverse prognosis of unmutated VH gene in patients with chronic lymphocytic leukemia [J].
Moreno, C ;
Villamor, N ;
Colomer, D ;
Esteve, J ;
Martino, R ;
Nomdedéu, J ;
Bosch, F ;
López-Guillermo, A ;
Campo, E ;
Sierra, J ;
Montserrat, E .
JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (15) :3433-3438
[6]   Dose-escalated donor lymphocyte inftisions following reduced intensity transplantation: toxicity, chimerism, and disease responses [J].
Peggs, KS ;
Thomson, K ;
Hart, DP ;
Geary, J ;
Morris, EC ;
Yong, K ;
Goldstone, AH ;
Linch, DC ;
Mackinnon, S .
BLOOD, 2004, 103 (04) :1548-1556
[7]   Evidence of a graft-versus-leukemia effect in chronic lymphocytic leukemia after reduced-intensity conditioning and allogeneic stem-cell transplantation:: The Cooperative German Transplant Study Group [J].
Schetelig, J ;
Thiede, C ;
Bornhäuser, M ;
Schwerdtfeger, R ;
Kiehl, M ;
Beyer, J ;
Sayer, HG ;
Kröger, N ;
Hensel, M ;
Scheffold, C ;
Held, TK ;
Höffken, K ;
Ho, AD ;
Kienast, J ;
Neubauer, A ;
Zander, AR ;
Fauser, AA ;
Ehninger, G ;
Siegert, W .
JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (14) :2747-2753
[8]   Hematopoietic cell transplantation after nonmyeloablative conditioning for advanced chronic lymphocytic leukemia [J].
Sorror, ML ;
Maris, MB ;
Sandmaier, BM ;
Storer, BE ;
Stuart, MJ ;
Hegenbart, U ;
Agura, E ;
Chauncey, TR ;
Leis, J ;
Pulsipher, M ;
McSweeney, P ;
Radich, JP ;
Bredeson, C ;
Bruno, B ;
Langston, A ;
Laken, MR ;
Al-Ali, H ;
Blume, KG ;
Storb, R ;
Maloney, DG .
JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (16) :3819-3829