Role of β-defensins in oral epithelial health and disease

被引：69

作者：

Abiko, Yoshihiro ^{[1
,2
]}

Saitoh, Masto ^{[1
,2
,3
]}

Nishimura, Michiko ^{[2
]}

Yamazaki, Mami ^{[2
]}

Sawamura, Daisuke ^{[4
]}

Kaku, Tohru ^{[2
]}

机构：

[1] Hlth Sci Univ Hokkaido, Inst Personalized Med Sci, Div Oral Med & Pathol, Dept Dent Sci,Kita Ku, Sapporo, Hokkaido 0028072, Japan

[2] Hlth Sci Univ Hokkaido, Sch Dent, Dept Human Biol & Pathophysiol, Div Clin Oral Pathol, Hokkaido, Japan

[3] Hlth Sci Univ Hokkaido, Sch Dent, Dept Oral Growth & Dev, Div Pediat Dent, Hokkaido, Japan

[4] Hirosaki Univ, Sch Med, Dept Dermatol, Hirosaki, Anmori 036, Japan

来源：

MEDICAL MOLECULAR MORPHOLOGY | 2007年 / 40卷 / 04期

关键词：

beta-defensins; antimicrobial peptide; oral epithelial diseases; SQUAMOUS-CELL CARCINOMA; ACTINOBACILLUS-ACTINOMYCETEMCOMITANS; GENE-EXPRESSION; ANTIMICROBIAL PEPTIDES; HUMAN BETA-DEFENSIN-1; GINGIVAL TISSUE; INNATE IMMUNITY; LOCAL-DELIVERY; MESSENGER-RNA; INFECTION;

D O I：

10.1007/s00795-007-0381-8

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The oral epithelium functions as a mechanical and protective barrier to resist bacterial infection. beta-Defensins are a group of antimicrobial peptides mainly produced by epithelial cells of many organs including skin, lung, kidney, pancreas, uterus, eye, and nasal and oral mucosa. This review focuses on beta-defensins (BDs) in oral epithelia and discusses their importance in oral epithelial health and disease. BDs exhibit antimicrobial activity against oral microbes including periodontitis-related bacteria, Candida, and papilloma virus. Alterative expression of BDs was observed in oral epithelial diseases, including oral inflammatory lesions with and without microbial infection and oral cancer. BDs may be useful in the treatment of oral infectious diseases, ulcerative lesions, and cancer. BDs play an important role in protection against oral microbes and may be used in clinical applications.

引用

页码：179 / 184

页数：6

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