The cyclooxygenase-2 structure: New drugs for an old target?

被引：31

作者：

Garavito, RM

机构：

[1] Department of Biochemistry, Michigan State University, East Lansing

来源：

NATURE STRUCTURAL BIOLOGY | 1996年 / 3卷 / 11期

关键词：

D O I：

10.1038/nsb1196-897

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The crystal structure of human cyclooxygenase-2 offers a unique opportunity for the design of new nonsteroidal anti-inflammatory drugs and may also provide insights into the mechanisms of membrane protein targeting and the role of prostaglandin physiology in inflammation and disease.

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页码：897 / 901

页数：5

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