Activity-dependent activation of presynaptic protein kinase C mediates post-tetanic potentiation

被引：73

作者：

Brager, DH ^{[1
]}

Cai, X ^{[1
]}

Thompson, SM ^{[1
]}

机构：

[1] Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA

来源：

NATURE NEUROSCIENCE | 2003年 / 6卷 / 06期

关键词：

D O I：

10.1038/nn1067

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Vesicle exocytosis is mediated by the complex interaction between synaptic vesicle and plasma membrane proteins, many of which are substrates for protein kinases(1-3). Exogenous protein kinase activators increase release probability at several mammalian CNS synapses(4-6), but the physiological conditions under which presynaptic protein kinases become activated are not known. We report here that calcium/phospholipid-dependent protein kinase C (PKC) is activated by high-frequency stimulation and mediates post-tetanic potentiation (PTP) in the rat hippocampus.

引用

页码：551 / 552

页数：2

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