Differential patterns of human immunoglobulin G subclass responses to distinct regions of a single protein, the merozoite surface protein 1 of Plasmodium falciparum

被引：59

作者：

Cavanagh, DR

Dobaño, C

Elhassan, IM

Marsh, K

Elhassan, A

Hviid, L

Khalil, EATG

Theander, TG

Arnot, DE

McBride, JS

机构：

[1] Univ Edinburgh, Inst Cell Anim & Populat Biol, Div Biol Sci, Edinburgh EH9 3JT, Midlothian, Scotland

[2] Univ Khartoum, Inst Endem Dis, Khartoum, Sudan

[3] KEMRI Ctr Geog Med Res Coast, Kilifi, Kenya

[4] Univ Copenhagen, Inst Med Microbiol & Immunol, Ctr Med Parasitol, Copenhagen, Denmark

[5] Univ Copenhagen Hosp, Dept Infect Dis, DK-2100 Copenhagen, Denmark

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 02期

关键词：

D O I：

10.1128/IAI.69.2.1207-1211.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Comparisons of immunoglobulin G (IgG) subclass responses to the major polymorphic region and to a conserved region of MSP-1 in three cohorts of African villagers exposed to Plasmodium falciparum revealed that responses to Block 2 are predominantly IgG3 whereas antibodies to MSP-1(19) are mainly IgG1. The striking dominance of IgG3 to Block 2 may explain the short duration of this response and also the requirement for continuous stimulation by malaria infection to maintain clinical immunity.

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页码：1207 / 1211

页数：5

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