Enantiomeric separation of amphetamine by high-performance liquid chromatography using chiral crown ether-coated reversed-phase packing: Application to forensic analysis

被引：22

作者：

Makino, Y

Ohta, S

Hirobe, M

机构：

[1] UNIV TOKYO,FAC MED,BUNKYO KU,TOKYO 113,JAPAN

[2] UNIV TOKYO,FAC PHARMACEUT SCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

FORENSIC SCIENCE INTERNATIONAL | 1996年 / 78卷 / 01期

关键词：

amphetamine; high-performance liquid chromatography; chiral crown ether column; norephedrine; optical resolution; primary amine;

D O I：

10.1016/0379-0738(95)01865-4

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

d-Amphetamine and l-amphetamine were clearly separated by HPLC analysis using a chiral crown ether column (CROWNPACK CR(+)). As little as 0.1% d-amphetamine in bulk methamphetamine could be determined. The enantiomeric form of the by-product in a drug sample may be helpful in evaluating thr possibility of illicit synthesis. When the isomeric composition of amphetamine present in urine from a methamphetamine abuser was examined, only d-amphetamine was detected as a metabolite. The present method was also applied to the enantiomeric separation of norephedrine.

引用

页码：65 / 70

页数：6

共 13 条

[1]

ALEMBIK MC, 1988, J ASSOC OFF ANA CHEM, V71, P530

[2]

DANIELS TC, 1977, TXB ORGANIC MED PHAR, P412

[3] ENANTIOSPECIFIC DRUG ANALYSIS VIA THE ORTHO-PHTHALALDEHYDE HOMOCHIRAL THIOL DERIVATIZATION METHOD [J].