Gene therapy to bet on: protecting neurons from stress hormones

被引：7

作者：

Akama, KT ^{[1
]}

McEwen, BS ^{[1
]}

机构：

[1] Rockefeller Univ, Dept Neuroendocrinol, New York, NY 10021 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2005年 / 26卷 / 04期

关键词：

D O I：

10.1016/j.tips.2005.02.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Glucocorticoids are adrenal steroid ' stress ' hormones that are important in normal brain function. However, during conditions of excitotoxic injury to neurons, glucocorticoids can exacerbate cell death. A recent study has developed a ' trifecta ' of ingenious viral vector-based approaches to modify the neuronal stress response and to diminish this exacerbation both in vitro and in vivo. Stress hormone gene therapy in the brain is now off and running.

引用

页码：169 / 172

页数：4

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