Synthesis of tetrocarcin derivatives with specific inhibitory activity towards Bcl-2 functions

被引：37

作者：

Kaneko, M

Nakashima, T

Uosaki, Y

Hara, M

Ikeda, S

Kanda, Y

机构：

[1] Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd, Machida, Tokyo 194-8533

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(01)00094-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Tetrocarcin A was recently identified as an inhibitor of the anti-apoptotic function of Bcl-2. We synthesized novel tetrocarcin derivatives in order to increase their selective inhibitory activity against Bcl-2. It was found that 21-acetoxy-9-glycosyloxy derivatives had potent Bcl-2 inhibitory activity without significant antimicrobial activity, (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：887 / 890

页数：4

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