Thiazolidinedione-associated congestive heart failure and pulmonary edema

被引:90
作者
Kermani, A
Garg, A
机构
[1] Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA
[2] Dept Vet Affairs Med Ctr, Dallas, TX USA
[3] Univ Texas, SW Med Ctr, Ctr Human Nutr, Dallas, TX 75390 USA
[4] Univ Texas, SW Med Ctr, Div Nutr & Metab Dis, Dallas, TX 75390 USA
关键词
D O I
10.4065/78.9.1088
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: To evaluate the effect of thiazolidinediones on the development of cardiac failure and pulmonary edema during treatment of type 2 diabetes mellitus. Patients and Methods: We retrospectively reviewed the medical records of 6 men (Aged 66 to 78 years) treated at our institution between August 1, 2001, and, May 21, 2002, who had type 2 diabetes and developed signs and symptoms of congestive heart failure and pulmonary edema after 1 to 16 months of therapy with pioglitazone or rosiglitazone. Results: Four patients had chronic renal insufficiency; only 1 had ischemic cardiomyopathy. Symptoms resolved promptly in all 6 patients after administration of diuretics and discontinuation of the thiazolidinedione. Conclusion: We conclude that thiazolidinediones can cause or exacerbate heart failure and pulmonary edema And should be avoided in patients with left ventricular dysfunction or chronic renal insufficiency.
引用
收藏
页码:1088 / 1091
页数:4
相关论文
共 6 条
  • [1] Troglitazone treatment increases plasma vascular endothelial growth factor in diabetic patients and its mRNA in 3T3-L1 adipocytes
    Emoto, M
    Anno, T
    Sato, Y
    Tanabe, K
    Okuya, S
    Tanizawa, Y
    Matsutani, A
    Oka, Y
    [J]. DIABETES, 2001, 50 (05) : 1166 - 1170
  • [2] Pulmonary edema associated with troglitazone therapy
    Hirsch, IB
    Kelly, J
    Cooper, S
    [J]. ARCHIVES OF INTERNAL MEDICINE, 1999, 159 (15) : 1811 - 1811
  • [3] Ridderstrale Martin, 2002, Lakartidningen, V99, P407
  • [4] Thomas ML, 2001, ANN PHARMACOTHER, V35, P123
  • [5] Peroxisome proliferator-activated receptor γ and metabolic disease
    Willson, TM
    Lambert, MH
    Kliewer, SA
    [J]. ANNUAL REVIEW OF BIOCHEMISTRY, 2001, 70 : 341 - 367
  • [6] Wooltorton E, 2002, CAN MED ASSOC J, V166, P219