Physical and molecular properties of agrochemicals: An analysis of screen inputs, hits, leads, and products

被引：83

作者：

Clarke, ED ^{[1
]}

Delaney, JS ^{[1
]}

机构：

[1] Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England

来源：

CHIMIA | 2003年 / 57卷 / 11期

关键词：

agrochemicals; bioavailability; design guidelines; property profiles; 'rule of five';

D O I：

10.2533/000942903777678641

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This work provides a comprehensive overview of agrochemical properties in terms of the way they change during progression from screen hit to product and in terms of their limits as expressed in modern commercial products. Most herbicides and fungicides readily meet the Lipinski 'rule of five' criteria for drug-like compounds with many meeting the more constrained limits reported for pharmaceutical leads.

引用

页码：731 / 734

页数：4

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