Elevated serum thiobarbituric acid reactive substances in clinically symptomatic schizophrenic males

被引：37

作者：

Gama, Clarissa Severino ^{[1
,2
,3
,5
]}

Salvador, Mirian ^{[8
]}

Andreazza, Ana Cristina ^{[2
,3
,4
,8
]}

Lobato, Maria Ines ^{[2
,3
,5
]}

Berk, Michael ^{[1
,6
,7
]}

Kapczinski, Flavio ^{[1
,2
,3
,4
]}

Belmonte-de-Abreu, Paulo Silva ^{[2
,3
,5
]}

机构：

[1] Univ Melbourne, Dept Clin & Biomed Sci, Geelong, Vic 3220, Australia

[2] Hosp Clin Porto Alegre, Ctr Pesquisas, Lab Psiquiatria Mol, BR-90035003 Porto Alegre, RS, Brazil

[3] Univ Fed Rio Grande do Sul, Programa Posgrad Med Psiquiatria, BR-90035003 Porto Alegre, RS, Brazil

[4] Hosp Clin Porto Alegre, Bipolar Disorders Program, BR-90035003 Porto Alegre, RS, Brazil

[5] Hosp Clin Porto Alegre, Schizophrenia Program, BR-90035003 Porto Alegre, RS, Brazil

[6] Orygen Res Ctr, Parkville, Vic, Australia

[7] Mental Hlth Res Inst, Parkville, Vic, Australia

[8] Univ Caxias Sul, Inst Biotecnol, BR-95070560 Caxias Do Sul, RS, Brazil

来源：

NEUROSCIENCE LETTERS | 2008年 / 433卷 / 03期

关键词：

schizophrenia; oxidative stress; peroxidative damage; clinical course; psychopathology;

D O I：

10.1016/j.neulet.2008.01.018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Impaired antioxidant defenses are suggested to participate in the pathophysiology of schizophrenia. Altered superoxide dismutase (SOD) and increased lipid peroxidation, measured by the thiobarbituric acid reactive substances (TBARS), are increased in schizophrenia. The aim of this study was to determine the effects of clinical course and subtype on oxidative stress parameters. In this study, 68 male patients, classified according to DSM-IV schizophrenia subtypes and clinical course (partial remission, marked symptoms, and deteriorated), were studied, and TBARS and SOD measured. Mean serum SOD and mean serum TBARS concentrations were similarly not significantly different among different subtypes (paranoid, disorganized and undifferentiated). However, marked symptoms status was associated with higher TBARS levels compared to the deteriorated group. This suggests a possible relationship between symptom acuity and oxidative stress in males. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：270 / 273

页数：4

共 32 条

[1] The indices of endogenous oxidative and antioxidative processes in plasma from schizophrenic patients The possible role of oxidant/antioxidant imbalance [J].