Apoptosis - DNA destroyers

被引：58

作者：

Hengartner, MO ^{[1
]}

机构：

[1] Univ Zurich, Inst Mol Biol, CH-8057 Zurich, Switzerland

来源：

NATURE | 2001年 / 412卷 / 6842期

关键词：

D O I：

10.1038/35083663

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Proteins with quite mundane functions in healthy cells often behave very differently during cell suicide. One protein normally involved in copying mitochondrial DNA actually degrades nuclear DNA in dying cells.

引用

页码：27 / 29

页数：2

共 9 条

[1] Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death [J].

Chen, FL ;

Hersh, BM ;

Conradt, B ;

Zhou, Z ;

Riemer, D ;

Gruenbaum, Y ;

Horvitz, HR .

SCIENCE, 2000, 287 (5457) :1485-1489

[2] PRIMERS FOR MITOCHONDRIAL-DNA REPLICATION GENERATED BY ENDONUCLEASE-G [J].

COTE, J ;

RUIZCARRILLO, A .

SCIENCE, 1993, 261 (5122) :765-769

[3] The biochemistry of apoptosis [J].

Hengartner, MO .

NATURE, 2000, 407 (6805) :770-776

[4] Endonuclease G is an apoptotic DNase when released from mitochondria [J].

Li, LY ;

Luo, L ;

Wang, XD .

NATURE, 2001, 412 (6842) :95-99

[5] Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death [J].

Lorenzo, HK ;

Susin, SA ;

Penninger, J ;

Kroemer, G .

CELL DEATH AND DIFFERENTIATION, 1999, 6 (06) :516-524

[6] Apoptotic DNA fragmentation [J].

Nagata, S .

EXPERIMENTAL CELL RESEARCH, 2000, 256 (01) :12-18

[7] Mitochondrial endonuclease G is important for apoptosis in C-elegans [J].

Parrish, J ;

Li, LL ;

Klotz, K ;

Ledwich, D ;

Wang, XD ;

Xue, D .

NATURE, 2001, 412 (6842) :90-94

[8]

Wu YC, 2000, GENE DEV, V14, P536

[9] GLUCOCORTICOID-INDUCED THYMOCYTE APOPTOSIS IS ASSOCIATED WITH ENDOGENOUS ENDONUCLEASE ACTIVATION [J].

WYLLIE, AH .

NATURE, 1980, 284 (5756) :555-556

← 1 →