Propargyloxycarbonyl and propargyl groups for novel protection of amino, hydroxy, and carboxy functions

被引：24

作者：

Fukase, Y ^{[1
]}

Fukase, K ^{[1
]}

Kusumoto, S ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Sci, Dept Chem, Osaka 5600043, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 06期

关键词：

propargyl; propargyloxycarbonyl; alkyne-Co complex; protecting group;

D O I：

10.1016/S0040-4039(98)02555-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The propargyloxycarbonyl group readily introduced to both amino and hydroxy groups by using propargyl chloroformate is stable to neat TFA but is readily cleaved at ambient temperature by treatment with Co-2(CO)(8) and TFA in CH2Cl2 via formation of an alkyne-Co complex. The propargyl ester similarly serves as a good protecting group for carboxy functions. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1169 / 1170

页数：2

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