B lymphocytes are required for development and treatment of autoimmune diseases

被引：32

作者：

Youinou, P ^{[1
]}

Jamin, C ^{[1
]}

Pers, JO ^{[1
]}

Berthou, C ^{[1
]}

Saraux, A ^{[1
]}

Renaudineau, Y ^{[1
]}

机构：

[1] Brest Univ, Sch Med, F-29609 Brest, France

来源：

AUTOIMMUNITY: CONCEPTS AND DIAGNOSIS AT THE CUTTING EDGE | 2005年 / 1050卷

关键词：

B lymphocyte; autoimmune disease; dendritic cell; T lymphocyte; B-cell antigen receptor; CD5;

D O I：

10.1196/annals.1313.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies have revealed that B cells serve extraordinarily diverse functions within the immune system in addition to antibody production. These functions contribute to autoimmunity. They initiate the development of lymphoid architecture and regulate dendritic and T-cell function through cytokine production. Receptor editing is also essential to prevent autoimmunity. Both abnormalities in the distribution of B-cell subsets and the benefits of ablative B-cell therapy of autoimmune states confirm their importance. Results from transgenic models have demonstrated that the sensitivity of B cells to antigen receptor cross-linking correlates to autoimmunity, with particular reference to negative signaling by CD5 and CD22. These mechanisms maintain tolerance by recruiting src-homology 2 domain-containing protein tyrosine phosphatase-1. These findings open new prospects for immunotherapy of autoimmune diseases.

引用

页码：19 / 33

页数：15

共 105 条

[1] Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation [J].