MRI-guided, open trial of abciximab for ischemic stroke within a 3-to 24-hour window

被引：10

作者：

Mitsias, PD

Lu, M

Silver, B

Morris, D

Ewing, JR

Daley, S

Lewandowski, C

Katramados, A

Papamitsakis, NI

Ebadian, HB

Zhao, Q

Soltanian-Zadeh, H

Hearshen, D

Patel, SC

Chopp, M

机构：

[1] Henry Ford Hlth Sci Ctr, Dept Neurol, Detroit, MI USA

[2] Henry Ford Hlth Sci Ctr, Dept Biostat & Res Epidemiol, Detroit, MI USA

[3] Henry Ford Hlth Sci Ctr, Dept Emergency Med, Detroit, MI USA

[4] Henry Ford Hlth Sci Ctr, Dept Radiol, Detroit, MI USA

[5] JFK Med Ctr, New Jersey Neurosci Inst, Edison, NJ USA

[6] Oakland Univ, Dept Med Phys, Rochester, MI 48063 USA

来源：

NEUROLOGY | 2005年 / 65卷 / 04期

关键词：

D O I：

10.1212/01.wnl.0000172862.33641.92

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors assessed the effect of IV abciximab on early neurologic improvement and ischemic lesion growth in 29 patients with supratentorial stroke and NIH stroke scale score (NIHSSS) >= 4 (11.1 +/- 5.9), treated within 3 to 24 (13.6 +/- 5.5) hours of onset. The 48 to 72-hour NIHSSS improvement was 4.4 +/- 3.2 and the 24-hour lesion growth on DWI was +23% (-50%, +103%); 7/26 (27%) patients experienced lesion size decrease. Treatment of sub-24-hour stroke with abciximab improves early post-treatment neurologic status and often attenuates ischemic lesion growth.

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页码：612 / 615

页数：4

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