Combinatorial effects of microRNAs to suppress the Myc oncogenic pathway

被引：48

作者：

Bueno, Mara J. ^{[1
,2
,3
,4
]}

Gomez de Cedron, Marta ^{[1
,2
]}

Gomez-Lopez, Gonzalo ^{[5
]}

Perez de Castro, Ignacio ^{[1
,2
]}

Di Lisio, Lorena ^{[6
]}

Montes-Moreno, Santiago ^{[6
]}

Martinez, Nerea ^{[6
]}

Guerrero, Manuel ^{[1
,2
,4
]}

Sanchez-Martinez, Ruth ^{[1
,2
]}

Santos, Javier ^{[3
,4
,7
]}

Pisano, David G. ^{[5
]}

Angel Piris, Miguel ^{[6
]}

Fernandez-Piqueras, Jose ^{[3
,4
,7
]}

Malumbres, Marcos ^{[1
,2
]}

机构：

[1] Ctr Nacl Invest Oncol, Cell Div, E-28029 Madrid, Spain

[2] Ctr Nacl Invest Oncol, Canc Grp, E-28029 Madrid, Spain

[3] Univ Autonoma Madrid, Ctr Biol Mol Severo Ochoa, CSIC, Madrid, Spain

[4] Univ Autonoma Madrid, Dept Biol, Madrid, Spain

[5] Ctr Nacl Invest Oncol, Bioinformat Unit, Madrid, Spain

[6] Ctr Nacl Invest Oncol, Lymphoma Grp, Madrid, Spain

[7] ISCIII, Ctr Invest Biomed Red Enfermedades Raras, Madrid, Spain

来源：

BLOOD | 2011年 / 117卷 / 23期

关键词：

C-MYC; TRANSCRIPTIONAL REGULATION; INHIBITOR P15(INK4B); GAMMA-IRRADIATION; EXPRESSION; LYMPHOMAS; CANCER; INACTIVATION; GENES; IDENTIFICATION;

D O I：

10.1182/blood-2010-10-315432

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Many mammalian transcripts contain target sites for multiple miRNAs, although it is not clear to what extent miRNAs may coordinately regulate single genes. We have mapped the interactions between down-regulated miRNAs and overexpressed target protein-coding genes in murine and human lymphomas. Myc, one of the hallmark oncogenes in these lymphomas, stands out as the up-regulated gene with the highest number of genetic interactions with down-regulated miRNAs in mouse lymphomas. The regulation of Myc by several of these miRNAs is confirmed by cellular and reporter assays. The same approach identifies MYC and multiple Myc targets as a preferential target of down-regulated miRNAs in human Burkitt lymphoma, a pathology characterized by translocated MYC oncogenes. These results indicate that several miRNAs must be coordinately down-regulated to enhance critical oncogenes, such as Myc. Some of these Myc-targeting miRNAs are repressed by Myc, suggesting that these tumors are a consequence of the unbalanced activity of Myc versus miRNAs. (Blood. 2011; 117(23): 6255-6266)

引用

页码：6255 / 6266

页数：12

共 50 条

[1] Adult Burkitt leukemia and lymphoma [J].

Blum, KA ;

Lozanski, G ;

Byrd, JC .

BLOOD, 2004, 104 (10) :3009-3020

[2] The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities [J].

Bonci, Desiree ;

Coppola, Valeria ;

Musumeci, Maria ;

Addario, Antonio ;

Giuffrida, Raffaella ;

Memeo, Lorenzo ;

D'Urso, Leonardo ;

Pagliuca, Alfredo ;

Biffoni, Mauro ;

Labbaye, Catherine ;

Bartucci, Monica ;

Muto, Giovanni ;

Peschle, Cesare ;

De Maria, Ruggero .

NATURE MEDICINE, 2008, 14 (11) :1271-1277

[3]

BRATHWAITE O, 1992, CANCER RES, V52, P3791

[4] Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression [J].

Bueno, Maria J. ;

Perez de Castro, Ignacio ;

de Cedron, Marta Gomez ;

Santos, Javier ;

Calin, George A. ;

Cigudosa, Juan C. ;

Croce, Carlo M. ;

Fernandez-Piqueras, Jose ;

Malumbres, Marcos .

CANCER CELL, 2008, 13 (06) :496-506

[5] Multiple E2F-Induced MicroRNAs Prevent Replicative Stress in Response to Mitogenic Signaling [J].

Bueno, Maria J. ;

Gomez de Cedron, Marta ;

Laresgoiti, Usua ;

Fernandez-Piqueras, Jose ;

Zubiaga, Ana M. ;

Malumbres, Marcos .

MOLECULAR AND CELLULAR BIOLOGY, 2010, 30 (12) :2983-2995

[6] Widespread microRNA repression by Myc contributes to tumorigenesis [J].

Chang, Tsung-Cheng ;

Yu, Duonan ;

Lee, Yun-Sil ;

Wentzel, Erik A. ;

Arking, Dan E. ;

West, Kristin M. ;

Dang, Chi V. ;

Thomas-Tikhonenko, Andrei ;

Mendell, Joshua T. .

NATURE GENETICS, 2008, 40 (01) :43-50

[7] Molecular diagnosis of Burkitt's lymphoma [J].

Dave, Sandeep S. ;

Fu, Kai ;

Wright, George W. ;

Lam, Lloyd T. ;

Kluin, Philip ;

Boerma, Evert-Jan ;

Greiner, Timothy C. ;

Weisenburger, Dennis D. ;

Rosenwald, Andreas ;

Ott, German ;

Mueller-Hermelink, Hans-Konrad ;

Gascoyne, Randy D. ;

Delabie, Jan ;

Rimsza, Lisa M. ;

Braziel, Rita M. ;

Grogan, Thomas M. ;

Campo, Elias ;

Jaffe, Elaine S. ;

Dave, Bhavana J. ;

Sanger, Warren ;

Bast, Martin ;

Vose, Julie M. ;

Armitage, James O. ;

Connors, Joseph M. ;

Smeland, Erlend B. ;

Kvaloy, Stein ;

Holte, Harald ;

Fisher, Richard I. ;

Miller, Thomas P. ;

Montserrat, Emilio ;

Wilson, Wyndham H. ;

Bahl, Manisha ;

Zhao, Hong ;

Yang, Liming ;

Powell, John ;

Simon, Richard ;

Chan, Wing C. ;

Staudt, Louis M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (23) :2431-2442

[8] Mantle cell lymphoma: transcriptional regulation by microRNAs [J].

Di Lisio, L. ;

Gomez-Lopez, G. ;

Sanchez-Beato, M. ;

Gomez-Abad, C. ;

Rodriguez, M. E. ;

Villuendas, R. ;

Ferreira, B. I. ;

Carro, A. ;

Rico, D. ;

Mollejo, M. ;

Martinez, M. A. ;

Menarguez, J. ;

Diaz-Alderete, A. ;

Gil, J. ;

Cigudosa, J. C. ;

Pisano, D. G. ;

Piris, M. A. ;

Martinez, N. .

LEUKEMIA, 2010, 24 (07) :1335-1342

[9] Checks and balances E2F-microRNA crosstalk in cancer control [J].

Emmrich, Stephan ;

Puetzer, Brigitte M. .

CELL CYCLE, 2010, 9 (13) :2555-2567

[10] Oncomirs - microRNAs with a role in cancer [J].

Esquela-Kerscher, A ;

Slack, FJ .

NATURE REVIEWS CANCER, 2006, 6 (04) :259-269

← 1 2 3 4 5 →