Caenorhabditis elegans as a model to study renal development and disease:: Sexy cilia

被引：38

作者：

Barr, MM ^{[1
]}

机构：

[1] Univ Wisconsin, Sch Pharm, Madison, WI 53705 USA

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2005年 / 16卷 / 02期

关键词：

D O I：

10.1681/ASN.2004080645

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The nematode Caenorhabditis elegans has no kidney per se, yet "the worm" has proved to be an excellent model to study renal-related issues, including tubulogenesis of the excretory canal, membrane transport and ion channel function, and human genetic diseases including autosomal dominant polycystic kidney disease (ADPKD). The goal of this review is to explain how C. elegans has provided insight into cilia development, cilia function, and human cystic kidney diseases.

引用

页码：305 / 312

页数：8

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