Copper-catalyzed allylic hydroxyamination and amination of alkenes with Boc-hydroxylamine

被引：26

作者：

Kalita, B ^{[1
]}

Nicholas, KM ^{[1
]}

机构：

[1] Univ Oklahoma, Dept Chem & Biochem, Norman, OK 73019 USA

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 09期

基金：

美国国家科学基金会;

关键词：

allylic amination; hydroxyamination; copper-catalyzed;

D O I：

10.1016/j.tetlet.2005.01.024

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Olefins react regioselectively with Boc-NHOH in the presence of Cu(I,II) salts to produce allyl-N(OH)(Boc) derivatives, apparently via the intermediacy of Boc-N=O; yields and rates are dramatically improved by the addition of H2O2. The corresponding allylamine derivatives, allyl-NH(Boc), are formed selectively from Boc-NHOH/olefin with CuBr/P(OEt)(3). (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1451 / 1453

页数：3

共 59 条

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