The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins

被引：549

作者：

McMahon, SB

Van Buskirk, HA

Dugan, KA

Copeland, TD

Cole, MD ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

[2] NCI, ABL Basic Res Program, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA

来源：

CELL | 1998年 / 94卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0092-8674(00)81479-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The c-Myc and E2F transcription factors are among the most potent regulators of cell cycle progression in higher eukaryotes. This report describes the isolation of a novel, highly conserved 434 kDa protein, designated TRRAP, which interacts specifically with the c-Myc N terminus and has homology to the ATM/PI3- kinase family. TRRAP also interacts specifically with the E2F-1 transactivation domain. Expression of transdominant mutants of the TRRAP protein or antisense RNA blocks c-Myc- and E1A-mediated oncogenic transformation. These data suggest that TRRAP is an essential cofactor for both the c-Myc and E1A/E2F oncogenic transcription factor pathways.

引用

页码：363 / 374

页数：12

共 54 条

[1] HOMOGENEOUSLY STAINING CHROMOSOMAL REGIONS CONTAIN AMPLIFIED COPIES OF AN ABUNDANTLY EXPRESSED CELLULAR ONCOGENE (C-MYC) IN MALIGNANT NEUROENDOCRINE CELLS FROM A HUMAN-COLON CARCINOMA [J].