Potential roles of antisense technology in cancer chemotherapy

被引：66

作者：

Crooke, ST ^{[1
]}

机构：

[1] ISIS Pharmaceut Inc, Carlsbad, CA 92008 USA

来源：

ONCOGENE | 2000年 / 19卷 / 56期

关键词：

antisense; mechanisms of action; gene functionalization; anticancer activity;

D O I：

10.1038/sj.onc.1204093

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antisense technology may play a major role in cancer chemotherapy. It is clearly a tool of exceptional value in the functionalization of genes and their validation as potential targets for cancer chemotherapy. Additionally, there is now substantial evidence that antisense drugs are safe, and a growing body of data showing activity in animal models of human disease including cancer, and suggesting efficacy in patients with cancer. In this article, I review the progress in the technology, the anticancer antisense drugs in development and potential roles that antisense technology might play.

引用

页码：6651 / 6659

页数：9

共 85 条

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