Disaccharide nucleosides and their enzymatic and chemical incorporation into oligonucleotides

被引:7
作者
Efimtseva, EV
Victorova, LS
Rodionov, AA
Ermolinsky, BS
Fomitcheva, MV
Tunitskaya, VL
Mikhailov, SN
Oivanen, M
Van Aerschot, A
Herdewijn, P
机构
[1] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 117984, Russia
[2] Univ Turku, Dept Chem, FIN-20014 Turku, Finland
[3] Katholieke Univ Leuven, Rega Inst, B-3000 Louvain, Belgium
关键词
D O I
10.1080/07328319808004701
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A high yield synthesis of different O-ribofuranosylnucleosides has been achieved. Kinetics of the acid-catalysed hydrolysis of disaccharide nucleosides has been studied. Chemical and enzymatic incorporation of 2'-O-ribofuranosylnucleoside residue into oligonucleotides was investigated.
引用
收藏
页码:1681 / 1684
页数:4
相关论文
共 9 条
[1]  
Efimtseva EV, 1996, COLLECT CZECH CHEM C, V61, pS206
[2]   MUTANTS OF T7 RNA-POLYMERASE THAT ARE ABLE TO SYNTHESIZE BOTH RNA AND DNA [J].
KOSTYUK, DA ;
DRAGAN, SM ;
LYAKHOV, DL ;
RECHINSKY, VO ;
TUNITSKAYA, VL ;
CHERNOV, BK ;
KOCHETKOV, SN .
FEBS LETTERS, 1995, 369 (2-3) :165-168
[3]  
LERNER LM, 1990, CHEM NUCLEOSIDES NUC, V2, P27
[4]   THE MODIFIED NUCLEOSIDES OF RNA - SUMMARY [J].
LIMBACH, PA ;
CRAIN, PF ;
MCCLOSKEY, JA .
NUCLEIC ACIDS RESEARCH, 1994, 22 (12) :2183-2196
[5]   An efficient synthesis and physico-chemical properties of 2'-O-D-ribofuranosylnucleosides, minor tRNA components [J].
Mikhailov, SN ;
Efimtseva, EV ;
Gurskaya, GV ;
Fomitcheva, MV ;
Meshkov, SV ;
Zavodnik, VE ;
DeBruyn, A ;
Janssen, G ;
Rozenski, J ;
Herdewijn, P .
JOURNAL OF CARBOHYDRATE CHEMISTRY, 1997, 16 (01) :75-92
[6]   SYNTHESIS AND PROPERTIES OF SOME 2'-O-D-RIBOFURANOSYL-NUCLEOSIDES [J].
MIKHAILOV, SN ;
DEBRUYN, A ;
HERDEWIJN, P .
NUCLEOSIDES & NUCLEOTIDES, 1995, 14 (3-5) :481-484
[7]   Ribosylation of pyrimidine 2'-deoxynucleosides [J].
Mikhailov, SN ;
DeClercq, E ;
Herdewijn, P .
NUCLEOSIDES & NUCLEOTIDES, 1996, 15 (7-8) :1323-1334
[8]  
MIKHAILOV SN, IN PRESS CARBOHYDR L
[9]   STUDIES ON THE SYNTHESIS OF O-RIBOSYL-ADENOSINE - A NEW MINOR NUCLEOSIDE OF TRANSFER-RNA [J].
NIEWCZYK, A ;
KRZYZANIAK, A ;
BARCISZEWSKI, J ;
MARKIEWICZ, WT .
NUCLEOSIDES & NUCLEOTIDES, 1991, 10 (1-3) :635-638