Calcium signaling

被引：3447

作者：

Clapham, David E. ^{[1
]}

机构：

[1] Harvard Univ, Childrens Hosp, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA

来源：

CELL | 2007年 / 131卷 / 06期

关键词：

D O I：

10.1016/j.cell.2007.11.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calcium ions (Ca2+) impact nearly every aspect of cellular life. This review examines the principles of Ca2+ signaling, from changes in protein conformations driven by Ca2+ to the mechanisms that control Ca2+ levels in the cytoplasm and organelles. Also discussed is the highly localized nature of Ca2+- mediated signal transduction and its specific roles in excitability, exocytosis, motility, apoptosis, and transcription.

引用

页码：1047 / 1058

页数：12

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