Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain

被引：138

作者：

Zippin, JH

Farrell, J

Huron, D

Kamenetsky, M

Hess, KC

Fischman, DA

Levin, LR

Buck, J

机构：

[1] Cornell Univ, Joan & Sanford I Weill Med Coll, Dept Pharmacol, New York, NY 10021 USA

[2] Cornell Univ, Joan & Sanford I Weill Med Coll, Triinst MD Phd Program, New York, NY 10021 USA

[3] Cornell Univ, Joan & Sanford I Weill Med Coll, Dept Cell & Dev Biol, New York, NY 10021 USA

[4] Cornell Univ, Grad Sch Med Sci, New York, NY 10021 USA

来源：

JOURNAL OF CELL BIOLOGY | 2004年 / 164卷 / 04期

关键词：

CREB; PKA; gene expression; compartmentalization; signal transduction;

D O I：

10.1083/jcb.200311119

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Bicarbonate-responsive "soluble" adenylyl cyclase resides, in part, inside the mammalian cell nucleus where it stimulates the activity of nuclear protein kinase A to phosphorylate the cAMP response element binding protein (CREB). The existence of this complete and functional, nuclear-localized cAMP pathway establishes that cAMP signals in intracellular microdomains and identifies an alternate pathway leading to CREB activation.

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页码：527 / 534

页数：8

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