Solid-State Stability of Indomethacin Solvates

被引：7

作者：

Joshi, Vidya ^{[1
]}

Stowell, Joseph G. ^{[1
]}

Byrn, Stephen R. ^{[1
]}

机构：

[1] Purdue Univ, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA

来源：

MOLECULAR CRYSTALS AND LIQUID CRYSTALS SCIENCE AND TECHNOLOGY SECTION A-MOLECULAR CRYSTALS AND LIQUID CRYSTALS | 1998年 / 313卷

关键词：

indomethacin; solid state; desolvation; kinetics; polymorphic transitions;

D O I：

10.1080/10587259808044286

中图分类号：

O7 [晶体学];

学科分类号：

0702 ; 070205 ; 0703 ; 080501 ;

摘要：

Desolvation kinetics of two indomethacin (IMC) solvates namely methanolate and tert-butyl alcohol (TBA) solvate were studied at 60-100 degrees C by isothermal thermogravimetric analysis. The solvates can transform to one of two true polymorphic forms, or Solid-state desolvation of IMC predominantly proceeds by a nucleation-limited mechanism as described by Avrami-Erofeev kinetics. The activation energies of desolvation as determined from these kinetic data were 34 1 kcal/mol and 17.6 kcal/mol for the methanol and TBA solvates respectively. The rank order of activation energy correlates well with the hydrogen-bonding strength and the crystal packing of the solvates. The methanolate desolvates to the metastable a form, whereas the TBA solvate desolvates to the equilibrium form at all the temperatures studied.

引用

页码：265 / 270

页数：6