Cleavage of rhamnose from ristocetin A removes its ability to induce platelet aggregation

被引：9

作者：

Bardsley, B

Williams, DH

Baglin, TP

机构：

[1] Univ Cambridge, Cambridge Ctr Mol Recognit, Chem Lab, Cambridge CB2 1EW, England

[2] Addenbrookes NHS Trust, Dept Clin Haematol, Cambridge CB2 2QQ, England

来源：

BLOOD COAGULATION & FIBRINOLYSIS | 1998年 / 9卷 / 03期

关键词：

naringinase; platelet aggregation; ristocetin;

D O I：

10.1097/00001721-199804000-00004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ristocetin A is used clinically as a tool for the measurement of von Willebrand protein due to its ability to induce the aggregation of platelets in plasma being proportional to the concentration of von Willebrand protein. The enzymatically induced cleavage of alpha-L-rhamnose from the tetrasaccharide of ristocetin A removes this ability to induce platelet aggregation in plasma, providing a possible insight into the structural basis for this effect.

引用

收藏

页码：241 / 244

页数：4

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