Plasma GABA predicts acute response to divalproex in mania

被引:45
作者
Petty, F
Rush, AJ
Davis, JM
Calabrese, JR
Kimmel, SE
Kramer, GL
Small, JG
Miller, MJ
Swann, AE
Orsulak, PJ
Blake, ME
Bowden, CL
机构
[1] UNIV TEXAS,SW MED CTR,DEPT PSYCHIAT,DALLAS,TX
[2] UNIV ILLINOIS,DEPT PSYCHIAT,CHICAGO,IL 60612
[3] ILLINOIS STATE PSYCHIAT INST,CHICAGO,IL 60612
[4] CASE WESTERN RESERVE UNIV,SCH MED,CLEVELAND,OH
[5] INDIANA UNIV,SCH MED,DEPT PSYCHIAT,INDIANAPOLIS,IN 46202
[6] LARUE D CARTER MEM HOSP,INDIANAPOLIS,IN
[7] UNIV TEXAS,SCH MED,DEPT PSYCHIAT,HOUSTON,TX
[8] ABBOTT LABS,ABBOTT PK,IL 60064
[9] UNIV TEXAS,HLTH SCI CTR,DEPT PSYCHIAT,SAN ANTONIO,TX 78284
[10] AUDIE L MURPHY MEM VET ADM MED CTR,SAN ANTONIO,TX
关键词
bipolar disorder; mania; GABA; divalproex; valproic acid; lithium; response prediction;
D O I
10.1016/0006-3223(95)00141-7
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Bipolar I, manic phase inpatients were treated with divalproex sodium, lithium, or placebo in a previously reported parallel group multicenter, double-blind, randomized controlled acute phase treatment trial. Plasma concentrations of gamma aminobutyric acid (GABA) were measured before and after treatment. Higher pretreatment plasma GABA levels were significantly (p = .04) related to a better clinical response to divalproex (n = 19). Pretreatment plasma GABA levels did not correlate with response to either lithium (n = 13) or placebo (n = 31). Following treatment with divalproex sodium, plasma GABA levels decreased significantly (p < .05), compared to placebo. Pretreatment plasma GABA levels were not related to overall severity of manic symptoms. Plasma GABA may predict response to pharmacologic agents acting on the GABA system.
引用
收藏
页码:278 / 284
页数:7
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