Hypoglycaemic effect of water extracts of Aegle marmelos fruits in streptozotocin diabetic rats

被引：87

作者：

Kamalakkannan, N ^{[1
]}

Prince, PSM ^{[1
]}

机构：

[1] Annamalai Univ, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2003年 / 87卷 / 2-3期

关键词：

Aegle marmelos; streptozotocin diabetes; fruit extract; plasma lipid peroxides; antioxidants;

D O I：

10.1016/S0378-8741(03)00148-X

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Aegle marmelos Corr. (Rutaceae) is widely used in Indian Ayurvedic medicine for the treatment of diabetes mellitus. The hypoglycaemic effect of the water extract of the fruits of Aegle marmelos was examined in streptozotocin-induced diabetic Wistar rats. Oral administration of the water extract (125 and 250 mg kg(-1)) twice a day for 4 weeks resulted in significant reductions in blood glucose, plasma thiobarbituric acid reactive substances. hydroperoxides, ceruloplasmin and a-tocopherol and a significant elevation in plasma reduced glutathione and Vitamin C in diabetic rats. The effect of the extract at a dose of 250 mg kg I was more effective than glibenclamide in restoring the values of these parameters. The results of this study clearly shows the hypoglycaemic activity of the fruit extract. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：207 / 210

页数：4

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