Macromolecular Inhibition of Quorum Sensing: Enzymes, Antibodies, and Beyond

被引:153
作者
Amara, Neri [1 ,2 ]
Krom, Bastiaan P. [3 ,4 ]
Kaufmann, Gunnar F. [5 ,6 ]
Meijler, Michael M. [1 ,2 ]
机构
[1] Ben Gurion Univ Negev, Dept Chem, Beer Sheva, Israel
[2] Ben Gurion Univ Negev, Natl Inst Biotechnol Negev, IL-84105 Beer Sheva, Israel
[3] Univ Med Ctr Groningen, Kolff Inst, Dept Biomed Engn, NL-9713 AV Groningen, Netherlands
[4] Univ Groningen, Groningen, Netherlands
[5] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[6] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
基金
欧洲研究理事会;
关键词
HOMOSERINE LACTONE ACYLASE; N-ACYLHOMOSERINE LACTONES; TO-CELL COMMUNICATION; VIRULENCE GENE-EXPRESSION; STAPHYLOCOCCUS-AUREUS; ERWINIA-CAROTOVORA; CRYSTAL-STRUCTURE; SINORHIZOBIUM-MELILOTI; MOLECULAR-MECHANISMS; QUENCHING LACTONASE;
D O I
10.1021/cr100101c
中图分类号
O6 [化学];
学科分类号
070301 [无机化学];
摘要
Different signaling systems have been discovered, with still more proteins and small molecules involved in QS likely to be uncovered in future. Interactions between plants and microorganisms are ubiquitous. The ascent of plants on land and its subsequent first interactions with soil microbes has been estimated to have occurred around 500 million years ago, and the ability of plants to defend themselves against continuous attacks of pathogens has been paramount to their evolutionary success. The first QSM-inactivating enzyme was identified by Dong by screening treated soil samples and laboratory bacterial collections. The use of AHL-degrading enzymes has been proposed as a strategy to attenuate bacterial virulence. Reimmann and co-workers reported that over-expression of aiiA homologues of two Bacillus spp in P. aeruginosa PAO1 resulted in decreased production of elastase (LasB).
引用
收藏
页码:195 / 208
页数:14
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