Encapsulation of Ole e 1 in biodegradable microparticles induces Th1 response in mice:: a potential vaccine for allergy

被引：27

作者：

Batanero, E ^{[1
]}

Barral, P ^{[1
]}

Villalba, M ^{[1
]}

Rodríguez, R ^{[1
]}

机构：

[1] Univ Complutense Madrid, Fac Ciencias Quim, Dept Bioquim & Biol Mol, E-28040 Madrid, Spain

来源：

JOURNAL OF CONTROLLED RELEASE | 2003年 / 92卷 / 03期

关键词：

poly(D; L-lactide-co-glycolide); microparticles; vaccine; allergen; olive pollen allergy;

D O I：

10.1016/S0168-3659(03)00337-7

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Ole e I is the most prevalent allergen of olive (Olea europaea) pollen. The suitability Of poly(D,L-lactide-co-glycolide) (PLG) microparticles as a vaccine delivery system for Ole e I in therapy against olive allergy has been evaluated. BALB/c Mice were immunized intraperitoneally with Ole e I in PLG microparticles. Encapsulated Ole e I induced specific and long-lasting antibodies that were predominantly of the IgG2a isotype. Splenic cells from immunized mice secreted in vitro IFN-gamma, but not IL-4, after stimulation with Ole e 1. These results suggest that Ole e 1-containing PLG microparticles elicit a specific Th1-type immune response and may become a promising concept for allergy vaccine. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：395 / 398

页数：4

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