A strictly "pair"-selective synthesis of conjugated diynes via Pd-catalyzed cross coupling of 1,3-diynylzincs: A superior alternative to the Cadiot-Chodkiewicz reaction

被引:51
作者
Negishi, E [1 ]
Hata, M [1 ]
Xu, CD [1 ]
机构
[1] Purdue Univ, Herbert C Brown Labs, W Lafayette, IN 47907 USA
关键词
D O I
10.1021/ol000270m
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
[GRAPHICS] A strictly "pair"-selective synthesis of conjugated diynes via Pd-catalyzed cross coupling of 1,3-diynylzincs is described. This method, like the Cadiot-Chodkiewicz reaction, requires three steps for the synthesis of (RC)-C-1=CC=CR2 from (RC)-C-1=CH, (RX)-X-2, and HC=CH. However, the high "pair"-selectivity permitting high yield production of the desired conjugated diynes without separation of symmetrical diynes promises to make the present protocol superior to the Cadiot-Chodkiewicz reaction in many cases.
引用
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页码:3687 / 3689
页数:3
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