共 57 条
Human population structure and genetic association studies
被引:86
作者:

Ziv, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Womens Hlth Clin Res Ctr, Div Gen Internal Med, San Francisco, CA 94115 USA

Burchard, EG
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Womens Hlth Clin Res Ctr, Div Gen Internal Med, San Francisco, CA 94115 USA
机构:
[1] Univ Calif San Francisco, Womens Hlth Clin Res Ctr, Div Gen Internal Med, San Francisco, CA 94115 USA
[2] Univ Calif San Francisco, Womens Hlth Clin Res Ctr, Div Pulm Med, Dept Med, San Francisco, CA 94115 USA
关键词:
admixture;
confounding;
human genetics;
population stratification;
population structure;
D O I:
10.1517/phgs.4.4.431.22758
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
Population substructure and recent admixture may confound the results of genetic association studies in unrelated individuals, leading to a potential excess of both false positive and false negative results. The possibility of false associations depends on the population sampled, the trait being studied and the marker being tested. Although family based tests of association avoid the possibility of confounding due to population substructure and admixture, association studies in unrelated individuals may be preferred in many situations due to their feasibility. Unlinked genetic markers may be used to detect confounding in association studies. In addition, the information from unlinked markers may be used to adjust genetic associations.
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页码:431 / 441
页数:11
相关论文
共 57 条
[1]
Sibling-based tests of linkage and association for quantitative traits
[J].
Allison, DB
;
Heo, M
;
Kaplan, N
;
Martin, ER
.
AMERICAN JOURNAL OF HUMAN GENETICS,
1999, 64 (06)
:1754-1764

Allison, DB
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ, Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, Obes Res Ctr, New York, NY 10025 USA

Heo, M
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ, Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, Obes Res Ctr, New York, NY 10025 USA

Kaplan, N
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ, Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, Obes Res Ctr, New York, NY 10025 USA

Martin, ER
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ, Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, Obes Res Ctr, New York, NY 10025 USA
[2]
The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
[J].
Altshuler, D
;
Hirschhorn, JN
;
Klannemark, M
;
Lindgren, CM
;
Vohl, MC
;
Nemesh, J
;
Lane, CR
;
Schaffner, SF
;
Bolk, S
;
Brewer, C
;
Tuomi, T
;
Gaudet, D
;
Hudson, TJ
;
Daly, M
;
Groop, L
;
Lander, ES
.
NATURE GENETICS,
2000, 26 (01)
:76-80

Altshuler, D
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Whitehead Inst, Ctr Genome Res, Cambridge, MA 02139 USA

Hirschhorn, JN
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Whitehead Inst, Ctr Genome Res, Cambridge, MA 02139 USA

Klannemark, M
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Whitehead Inst, Ctr Genome Res, Cambridge, MA 02139 USA

Lindgren, CM
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Whitehead Inst, Ctr Genome Res, Cambridge, MA 02139 USA

Vohl, MC
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Whitehead Inst, Ctr Genome Res, Cambridge, MA 02139 USA

Nemesh, J
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Whitehead Inst, Ctr Genome Res, Cambridge, MA 02139 USA

Lane, CR
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Whitehead Inst, Ctr Genome Res, Cambridge, MA 02139 USA

Schaffner, SF
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Whitehead Inst, Ctr Genome Res, Cambridge, MA 02139 USA

Bolk, S
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Whitehead Inst, Ctr Genome Res, Cambridge, MA 02139 USA

Brewer, C
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Whitehead Inst, Ctr Genome Res, Cambridge, MA 02139 USA

Tuomi, T
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Whitehead Inst, Ctr Genome Res, Cambridge, MA 02139 USA

Gaudet, D
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Whitehead Inst, Ctr Genome Res, Cambridge, MA 02139 USA

Hudson, TJ
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Whitehead Inst, Ctr Genome Res, Cambridge, MA 02139 USA

Daly, M
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Whitehead Inst, Ctr Genome Res, Cambridge, MA 02139 USA

Groop, L
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Whitehead Inst, Ctr Genome Res, Cambridge, MA 02139 USA

Lander, ES
论文数: 0 引用数: 0
h-index: 0
机构: MIT, Whitehead Inst, Ctr Genome Res, Cambridge, MA 02139 USA
[3]
Testing for population subdivision and association in four case-control studies
[J].
Ardlie, KG
;
Lunetta, KL
;
Seielstad, M
.
AMERICAN JOURNAL OF HUMAN GENETICS,
2002, 71 (02)
:304-311

Ardlie, KG
论文数: 0 引用数: 0
h-index: 0
机构: Genom Collaborat, Cambridge, MA 02139 USA

Lunetta, KL
论文数: 0 引用数: 0
h-index: 0
机构: Genom Collaborat, Cambridge, MA 02139 USA

Seielstad, M
论文数: 0 引用数: 0
h-index: 0
机构: Genom Collaborat, Cambridge, MA 02139 USA
[4]
The power of genomic control
[J].
Bacanu, SA
;
Devlin, B
;
Roeder, K
.
AMERICAN JOURNAL OF HUMAN GENETICS,
2000, 66 (06)
:1933-1944

Bacanu, SA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15213 USA

论文数: 引用数:
h-index:
机构:

论文数: 引用数:
h-index:
机构:
[5]
Association studies for quantitative traits in structured populations
[J].
Bacanu, SA
;
Devlin, B
;
Roeder, K
.
GENETIC EPIDEMIOLOGY,
2002, 22 (01)
:78-93

Bacanu, SA
论文数: 0 引用数: 0
h-index: 0
机构: Carnegie Mellon Univ, Dept Stat, Pittsburgh, PA 15213 USA

论文数: 引用数:
h-index:
机构:

论文数: 引用数:
h-index:
机构:
[6]
HIGH-RESOLUTION OF HUMAN EVOLUTIONARY TREES WITH POLYMORPHIC MICROSATELLITES
[J].
BOWCOCK, AM
;
RUIZLINARES, A
;
TOMFOHRDE, J
;
MINCH, E
;
KIDD, JR
;
CAVALLISFORZA, LL
.
NATURE,
1994, 368 (6470)
:455-457

BOWCOCK, AM
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV, DEPT GENET, STANFORD, CA 94305 USA

RUIZLINARES, A
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV, DEPT GENET, STANFORD, CA 94305 USA

TOMFOHRDE, J
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV, DEPT GENET, STANFORD, CA 94305 USA

MINCH, E
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV, DEPT GENET, STANFORD, CA 94305 USA

KIDD, JR
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV, DEPT GENET, STANFORD, CA 94305 USA

CAVALLISFORZA, LL
论文数: 0 引用数: 0
h-index: 0
机构: STANFORD UNIV, DEPT GENET, STANFORD, CA 94305 USA
[7]
The importance of race and ethnic background in biomedical research and clinical practice
[J].
Burchard, EG
;
Ziv, E
;
Coyle, N
;
Gomez, SL
;
Tang, H
;
Karter, AJ
;
Mountain, JL
;
Pérez-Stable, EJ
;
Sheppard, D
;
Risch, N
.
NEW ENGLAND JOURNAL OF MEDICINE,
2003, 348 (12)
:1170-1175

Burchard, EG
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Lung Biol Ctr, San Francisco, CA 94143 USA Univ Calif San Francisco, Lung Biol Ctr, San Francisco, CA 94143 USA

Ziv, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Lung Biol Ctr, San Francisco, CA 94143 USA

Coyle, N
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Lung Biol Ctr, San Francisco, CA 94143 USA

Gomez, SL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Lung Biol Ctr, San Francisco, CA 94143 USA

Tang, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Lung Biol Ctr, San Francisco, CA 94143 USA

Karter, AJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Lung Biol Ctr, San Francisco, CA 94143 USA

Mountain, JL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Lung Biol Ctr, San Francisco, CA 94143 USA

Pérez-Stable, EJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Lung Biol Ctr, San Francisco, CA 94143 USA

Sheppard, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Lung Biol Ctr, San Francisco, CA 94143 USA

Risch, N
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Lung Biol Ctr, San Francisco, CA 94143 USA
[8]
Population stratification and spurious allelic association
[J].
Cardon, LR
;
Palmer, LJ
.
LANCET,
2003, 361 (9357)
:598-604

Cardon, LR
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

Palmer, LJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England
[9]
ADMIXTURE AS A TOOL FOR FINDING LINKED GENES AND DETECTING THAT DIFFERENCE FROM ALLELIC ASSOCIATION BETWEEN LOCI
[J].
CHAKRABORTY, R
;
WEISS, KM
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1988, 85 (23)
:9119-9123

CHAKRABORTY, R
论文数: 0 引用数: 0
h-index: 0
机构: PENN STATE UNIV,DEPT ANTHROPOL,UNIVERSITY PK,PA 16802

WEISS, KM
论文数: 0 引用数: 0
h-index: 0
机构: PENN STATE UNIV,DEPT ANTHROPOL,UNIVERSITY PK,PA 16802
[10]
A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission
[J].
Clayton, D
.
AMERICAN JOURNAL OF HUMAN GENETICS,
1999, 65 (04)
:1170-1177

Clayton, D
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Publ Hlth, MRC, Biostat Unit, Cambridge CB2 2SR, England Inst Publ Hlth, MRC, Biostat Unit, Cambridge CB2 2SR, England