Human population structure and genetic association studies

被引:86
作者
Ziv, E
Burchard, EG
机构
[1] Univ Calif San Francisco, Womens Hlth Clin Res Ctr, Div Gen Internal Med, San Francisco, CA 94115 USA
[2] Univ Calif San Francisco, Womens Hlth Clin Res Ctr, Div Pulm Med, Dept Med, San Francisco, CA 94115 USA
关键词
admixture; confounding; human genetics; population stratification; population structure;
D O I
10.1517/phgs.4.4.431.22758
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Population substructure and recent admixture may confound the results of genetic association studies in unrelated individuals, leading to a potential excess of both false positive and false negative results. The possibility of false associations depends on the population sampled, the trait being studied and the marker being tested. Although family based tests of association avoid the possibility of confounding due to population substructure and admixture, association studies in unrelated individuals may be preferred in many situations due to their feasibility. Unlinked genetic markers may be used to detect confounding in association studies. In addition, the information from unlinked markers may be used to adjust genetic associations.
引用
收藏
页码:431 / 441
页数:11
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