Association of polymorphisms of the tumour necrosis factor receptors I and II and rheumatoid arthritis

被引：14

作者：

Bayley, JP

Bakker, AM

Kaijzel, EL

Huizinga, TWJ

Verweij, CL

机构：

[1] Free Univ Amsterdam, Med Ctr, Dept Mol Cell Biol, NL-1081 BT Amsterdam, Netherlands

[2] Leiden Univ, Dept Rheumatol, Med Ctr, NL-2300 RC Leiden, Netherlands

[3] TNO Prevent & Hlth, Vasc & Connect Tissue Res Div, NL-2301 CE Leiden, Netherlands

来源：

RHEUMATOLOGY | 2003年 / 42卷 / 08期

关键词：

TNF receptor; rheumatoid arthritis; polymorphism; association study;

D O I：

10.1093/rheumatology/keg267

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To assess the role of polymorphisms of the tumour necrosis factor (TNF) receptors, TNF-RI (p55) and TNF-RII (p75) in the susceptibility to and severity of rheumatoid arthritis (RA) in Dutch patients. Methods. A total of 319 consecutive RA patients, and a cohort of 90 female RA patients with detailed 12-yr follow-up were genotyped for the TNF-RI exon 1 (+36 A to G) and TNF-RII 3' UTR (+1690 T to C) polymorphisms. Results. The frequencies of the TNF-RI and TNF-RII polymorphisms were determined in both patient groups and healthy controls, but no significant differences were found. To determine the relationship of these polymorphisms to disease severity, the extent of joint damage in the cohort of 90 female RA patients was analysed. No differences in severity were observed. Conclusion. These TNF-RI and TNF-RII polymorphisms were not found to be associated with susceptibility to or severity of RA in the Dutch population.

引用

页码：969 / 971

页数：3

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