TargetFinder: a software for antisense oligonucleotide target site selection based on MAST and secondary structures of target mRNA

被引：98

作者：

Bo, XC ^{[1
]}

Wang, SQ ^{[1
]}

机构：

[1] Beijing Inst Radiat Med, Beijing 100850, Peoples R China

来源：

BIOINFORMATICS | 2005年 / 21卷 / 08期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1093/bioinformatics/bti211

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

TargetFinder is a PC/Windows program for interactive effective antisense oligonucleotide (AO) selection based on mRNA accessible site tagging (MAST) and secondary structures of target mRNA. To make MAST result intuitive, both the alignment result and tag frequency profile is illustrated. As theoretical reference, secondary structure and single strand probability profile of target mRNA is also represented. All of these sequences and profiles are displayed in aligned mode, which facilitates identification of the accessible sites in target mRNA. Graphical, user-friendly interface makes TargetFinder a useful tool in AO target site selection.

引用

页码：1401 / 1402

页数：2

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