T cell fate specification and αβ/γδ lineage commitment

被引：40

作者：

MacDonald, HR ^{[1
]}

Radtke, F ^{[1
]}

Wilson, A ^{[1
]}

机构：

[1] Univ Lausanne, Ludwig Inst Canc Res, Lausanne Branch, CH-1066 Epalinges, Switzerland

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(00)00207-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of T cells from pluripotent stem cells involves a coordinated series of lineage-commitment steps. Common lymphoid precursors in the fetal liver or adult bone marrow must first choose between T, B or NK cell fate. Committed T cell precursors in the thymus then differentiate into cells committed to the alpha beta or gamma delta lineages. Recent advances have been made in our understanding of the mechanisms underlying T cell fate specification and alpha beta/gamma delta lineage divergence.

引用

页码：219 / 224

页数：6

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