Inhibition of chitin synthetase from Saccharomyces cerevisiae by a new UDP-GlcNAc analogue

被引：13

作者：

Behr, JB

Gautier-Lefebvre, I

Mvondo-Evina, C

Guillerm, G

Ryder, NS

机构：

[1] UFR Sci, UMR 6519, Chim Bioorgan Lab, F-51687 Reims, France

[2] Novartis Res Inst, A-1235 Vienna, Austria

来源：

JOURNAL OF ENZYME INHIBITION | 2001年 / 16卷 / 02期

关键词：

chitin synthetase; inhibition; transition state analogue; glycosyltransferase; azasugar nucleotide; UDP-GlcNAc analogue;

D O I：

10.1080/14756360109162360

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis and biological evaluation of a new UDP-GlcNAc competitor (I), designed to mimic the transition state of the sugar donor in the enzymatic reaction catalysed by chitin synthetase, is described. Compound (I) was found to competitively inhibit chitin synthetase from Saccharomyces cerevisiae with respect to UDP-G1cNAc, but displayed minimal antifungal activity.

引用

页码：107 / 112

页数：6

共 29 条

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