Homocysteine effects on brain volumes mapped in 732 elderly individuals

被引：61

作者：

Rajagopalan, Priya ^{[1
]}

Hua, Xue ^{[1
]}

Toga, Arthur W. ^{[1
]}

Jack, Clifford R., Jr. ^{[2
]}

Weiner, Michael W. ^{[3
,4
]}

Thompson, Paul M. ^{[1
]}

机构：

[1] UCLA Sch Med, Lab Neuro Imaging, Dept Neurol, Los Angeles, CA 90095 USA

[2] Mayo Clin, Dept Radiol, Rochester, MN USA

[3] Univ Calif San Francisco, Dept Radiol Med & Psychiat, San Francisco, CA 94143 USA

[4] Dept Vet Affairs Med Ctr, San Francisco, CA USA

来源：

NEUROREPORT | 2011年 / 22卷 / 08期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; atrophy; brain structure; folate; homocysteine; magnetic resonance imaging; vitamin B; ALZHEIMERS-DISEASE; MRI; BIOMARKER; ATROPHY; FOLATE;

D O I：

10.1097/WNR.0b013e328346bf85

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Elevated homocysteine levels are a known risk factor for Alzheimer's disease and vascular disorders. Here we applied tensor-based morphometry to brain magnetic resonance imaging scans of 732 elderly individuals from the Alzheimer's Disease Neuroimaging Initiative study, to determine associations between homocysteine and brain atrophy. Those with higher homocysteine levels showed greater frontal, parietal, and occipital white matter atrophy in the entire cohort, irrespective of diagnosis, age, or sex. This association was also found when considering mild cognitive impairment individuals separately. Vitamin B supplements, such as folate, may help prevent homocysteine-related atrophy in Alzheimer's disease by possibly reducing homocysteine levels. These atrophy profiles may, in the future, offer a potential biomarker to gauge the efficacy of interventions using dietary folate supplementation. NeuroReport 22:391-395 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.

引用

页码：391 / 395

页数：5

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